التفاصيل البيبلوغرافية
| العنوان: |
Synergistic Antimicrobial Action of Polymerized Indole-Based Nanocomposites with NfAg on Chemically Reformed Multiple-Layered Carbon Nanotubes. |
| المؤلفون: |
Ismaili, Hamit, Mustafa, Syed Khalid, Omer, Noha, Jame, Rasha, Shakeel, Nimra, Ahamed, Mohd Imran |
| المصدر: |
BioNanoScience; Nov2024, Vol. 14 Issue 4, p4469-4480, 12p |
| مستخلص: |
To ensure continued efficacy in combating infection globally for emerging strains of antimicrobial or antibacterial, it is indispensable to develop effective strategies against pathogens. Additionally, the necessity of antimicrobial agents lies in their ability to combat infectious microorganisms, safeguard public health, and reduce disease burden. Therefore, this work investigates the antibacterial abilities of specifically developed polymer nanocomposites, pI(nfAg-rMLCNTs), highlighting a potential way to tackle microbial concerns. We present a simple polymerized monomer of indole (pI) linked with silver nanoflakes (nfAg), which is blended into chemically reformed multiple-layered carbon nanotubes (rMLCNTs), which provides improved antibacterial characteristics. The synthesis is accomplished using an easy in situ polymerization approach coupled with chemical oxidation, resulting in the simultaneous development of polymers and nano-elements. The nfAg are scattered proportionally throughout the polymeric Indole matrix, with an average size distribution of 170 nm. Our findings show that these nanocomposites work synergistically against four pathogenic strains: Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa), and Klebsiella pneumonia (K. pneumonia). The resultant nanocomposite has substantially stronger antibacterial activity than individual components operating alone. Various analytical techniques were used to determine the prepared nanocomposites' optical, structural, and chemical properties, including UV–visible spectroscopy, transmission electron microscopy, scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy. Antibacterial activity quantification with varying degrees of inhibition shows considerable microbial growth suppression. The synergistic combination of nfAg with rMLCNT and polymerized monomer of indole (pI) results in potent antimicrobial activity against biofilm-forming bacteria, making pI(nfAg-rMLCNTs) nanocomposites a promising candidate for combating biofilm-associated infections in the health care sector. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |