التفاصيل البيبلوغرافية
| العنوان: |
Ovariectomy and High Fat-Sugar-Salt Diet Induced Alzheimer's Disease/Vascular Dementia Features in Mice. |
| المؤلفون: |
Sweetat, Sahar, Shabat, Moti Ben, Theotokis, Paschalis, Suissa, Nir, Karafoulidou, Eleni, Touloumi, Olga, Abu-Fanne, Rami, Abramsky, Oded, Wolf, Gilly, Saada, Ann, Lotan, Amit, Grigoriadis, Nikolaos, Rosenmann, Hanna |
| المصدر: |
Aging & Disease; Oct2024, Vol. 15 Issue 5, p2284-2300, 17p |
| مصطلحات موضوعية: |
OVARIECTOMY, ALZHEIMER'S disease, GLUCOSE |
| مستخلص: |
While the vast majority of Alzheimer's disease (AD) is non-familial, the animal models of AD that are commonly used for studying disease pathogenesis and development of therapy are mostly of a familial form. We aimed to generate a model reminiscent of the etiologies related to the common late-onset Alzheimer's disease (LOAD) sporadic disease that will recapitulate AD/dementia features. Naïve female mice underwent ovariectomy (OVX) to accelerate aging/menopause and were fed a high fat-sugar-salt diet to expose them to factors associated with increased risk of development of dementia/AD. The OVX mice fed a high fat-sugar-salt diet responded by dysregulation of glucose/insulin, lipid, and liver function homeostasis and increased body weight with slightly increased blood pressure. These mice developed AD-brain pathology (amyloid and tangle pathologies), gliosis (increased burden of astrocytes and activated microglia), impaied blood vessel density and neoangiogenesis, with cognitive impairment. Thus, OVX mice fed on a high fat-sugar-salt diet imitate a non-familial sporadic/environmental form of AD/dementia with vascular damage. This model is reminiscent of the etiologies related to the LOAD sporadic disease that represents a high portion of AD patients, with an added value of presenting concomitantly AD and vascular pathology, which is a common condition in dementia. Our model can, thereby, provide a valuable tool for studying disease pathogenesis and for the development of therapeutic approaches. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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