التفاصيل البيبلوغرافية
| العنوان: |
Bithiophene and coumestan derivatives from Eclipta prostrata (L.) L. and their hepatoprotective activity. |
| المؤلفون: |
Giang, Le Thi, Park, SeonJu, Cuc, Nguyen Thi, Tai, Bui Huu, Kiem, Phan Van, Hang, Nguyen Thi Minh, Ban, Ninh Khac, Cuong, Pham Van, Nhiem, Nguyen Xuan |
| المصدر: |
Journal of Asian Natural Products Research; Nov2024, Vol. 26 Issue 11, p1381-1387, 7p |
| مصطلحات موضوعية: |
PLANT anatomy, HIGH performance liquid chromatography, IN vitro studies, NUCLEAR magnetic resonance spectroscopy, RESEARCH funding, PHYTOESTROGENS, DESCRIPTIVE statistics, PLANT extracts, LIVER cells, MEDICINAL plants, RESEARCH, LIVER, CELL survival, MAPS |
| مستخلص: |
One new bithiophene derivative, 5-(but-3-en-1-yn-1-yl)-5′-(methoxymethyl)-2,2′-bithiophene (1), along with twelve known compounds, senecioester (2), tiglinsaureester (3), 5-acetoxymethyl-2′-(but-3-en-1-yn-1-yl)-2,5′-bithiophene (4), 5-(4-isovaleroyloxybut-1-ynyl)-2,2′-bithiophene (5), 5-hydroxymethyl-(2,5′:2′,5′′)-terthienyl tiglate (6), 5-hydroxymethyl-(2,5′:2′,5′′)-terthienyl agelate (7), 5- hydroxymethyl-2,5′:2′,5′′-terthiophene dimethylacrylate (8), 5-methoxymethyl-2,2′:5′,2′′-terthiophene (9), α-terthiophene (10), 1,3,8,9-tetrahydroxycoumestan 3-sulfate (11), demethylwedelolactone (12), and wedelolactone (13) were isolated from the methanol extract of aerial parts of Eclipta prostrata (L.) L. All isolated compounds were evaluated for the protective ability on the HepG2 cells. At the concentration of 100 μM, compounds 11-13 showed the highest hepatoprotective effects, with HepG2 cell viability ranging from 38.68% to 48.54%. Bithiophenes showed higher hepatoprotective cell viability than terthiophenes. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Asian Natural Products Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |