التفاصيل البيبلوغرافية
| العنوان: |
Postnatal Allergic Inhalation Induces Glial Inflammation in the Olfactory Bulb and Leads to Autism-Like Traits in Mice. |
| المؤلفون: |
Tanaka, Eizo, Yamasaki, Ryo, Saitoh, Ban-yu, Abdelhadi, Amina, Nagata, Satoshi, Yoshidomi, Sato, Inoue, Yuka, Matsumoto, Koichiro, Kira, Jun-ichi, Isobe, Noriko |
| المصدر: |
International Journal of Molecular Sciences; Oct2024, Vol. 25 Issue 19, p10464, 17p |
| مصطلحات موضوعية: |
OLFACTORY cortex, OLFACTORY bulb, AUTISM spectrum disorders, EOSINOPHIL disorders, ALLERGIC rhinitis, NASAL mucosa |
| مستخلص: |
Autism spectrum disorder (ASD) is one of the most prevalent neurodevelopmental disorders. To explore its pathophysiology, we investigated the association between neonatal allergic exposure and behavioral changes. Adult female C57BL/6J mice were immunized with adjuvant (aluminum hydroxide) or ovalbumin emulsified with adjuvant. After immunization, the mice were mated, and offspring were born at full term. The postnatal dams and infants were then simultaneously exposed to an allergen (ovalbumin) or vehicle via inhalation. After weaning, behavioral testing and histopathological analyses were conducted on male offspring. Compared with the vehicle-exposed offspring, the ovalbumin-exposed offspring had decreased sociability and increased repetitive behavior, thus representing an ASD-like phenotype in mice. Moreover, histopathological analyses revealed that the ovalbumin-exposed mice had increased astroglial, microglial, and eosinophilic infiltration in the olfactory bulb, as well as increased eosinophils in the nasal mucosa. The ovalbumin-exposed mice also had decreased dendritic spine density and a lower proportion of mature spines, suggesting the impairment of stimulus-induced synaptogenesis. In conclusion, postnatal allergic exposure induced an ASD-like phenotype, as well as allergic rhinitis, which was followed by glial inflammation in the olfactory bulb parenchyma. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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