التفاصيل البيبلوغرافية
| العنوان: |
In Vitro Antioxidant, Anti-Inflammatory Activity and Bioaccessibility of Ethanolic Extracts from Mexican Moringa oleifera Leaf. |
| المؤلفون: |
Herman-Lara, Erasmo, Rodríguez-Miranda, Jesús, Ávila-Manrique, Stefany, Dorado-López, Celia, Villalva, Marisol, Jaime, Laura, Santoyo, Susana, Martínez-Sánchez, Cecilia E. |
| المصدر: |
Foods; Sep2024, Vol. 13 Issue 17, p2709, 17p |
| مصطلحات موضوعية: |
HIGH performance liquid chromatography, MORINGA oleifera, PHENOLS, ACID derivatives, OXIDATIVE stress, ETHANOL |
| مستخلص: |
This study aimed to assess the antioxidant and anti-inflammatory properties, and bioaccessibility of Moringa oleifera ethanolic extracts using pressurized liquid extraction with varying ethanol concentrations (0%, 30%, 50%, 70%, and 100%) in water–ethanol mixtures. Quercetin derivatives and neochlorogenic acid were identified as major compounds via high-performance liquid chromatography with diode array detection. The 70% ethanol extract displayed the highest antioxidant activity and phenolic content, highlighting a strong correlation between phenolics and antioxidant potential. Extracts prepared with 50% and 70% ethanol (30 μg/mL) significantly inhibited TNF-α, IL-1β, and IL-6 cytokine secretion, with the 70% ethanol extract demonstrating robust anti-inflammatory effects. During in vitro digestion (oral, gastric, and intestinal phases), minimal changes were noted in most phenolic compounds' post-oral phase, but reductions occurred after the gastric phase. Substantial decreases in major compounds and antioxidant activity were observed in post-gastric and intestinal phases. Overall, ethanolic extracts of Moringa oleifera, particularly those with 70% ethanol, exhibit promising antioxidant and anti-inflammatory properties, suggesting potential for developing therapeutic agents against oxidative stress and inflammation-related disorders. However, it is essential to protect these compounds to prevent their degradation during digestion. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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