التفاصيل البيبلوغرافية
| العنوان: |
Recruited atypical Ly6G+ macrophages license alveolar regeneration after lung injury. |
| المؤلفون: |
Ruscitti, Cecilia, Abinet, Joan, Maréchal, Pauline, Meunier, Margot, de Meeûs, Constance, Vanneste, Domien, Janssen, Pierre, Dourcy, Mickael, Thiry, Marc, Bureau, Fabrice, Schneider, Christoph, Machiels, Benedicte, Hidalgo, Andres, Ginhoux, Florent, Dewals, Benjamin G., Guiot, Julien, Schleich, Florence, Garigliany, Mutien-Marie, Bellahcène, Akeila, Radermecker, Coraline |
| المصدر: |
Science Immunology; 2024, Vol. 9 Issue 98, p1-19, 19p |
| مصطلحات موضوعية: |
GRANULOCYTE-macrophage colony-stimulating factor, MYELOID cells, ALVEOLAR macrophages, CELL populations, EPITHELIAL cells |
| مستخلص: |
The lung is constantly exposed to airborne pathogens and particles that can cause alveolar damage. Hence, appropriate repair responses are essential for gas exchange and life. Here, we deciphered the spatiotemporal trajectory and function of an atypical population of macrophages after lung injury. Post–influenza A virus (IAV) infection, short-lived monocyte-derived Ly6G-expressing macrophages (Ly6G+ Macs) were recruited to the alveoli of lung perilesional areas. Ly6G+ Macs engulfed immune cells, exhibited a high metabolic potential, and clustered with alveolar type 2 epithelial cells (AT2s) in zones of active epithelial regeneration. Ly6G+ Macs were partially dependent on granulocyte-macrophage colony-stimulating factor and interleukin-4 receptor signaling and were essential for AT2-dependent alveolar regeneration. Similar macrophages were recruited in other models of injury and in the airspaces of lungs from patients with suspected pneumonia. This study identifies perilesional alveolar Ly6G+ Macs as a spatially restricted, short-lived macrophage subset promoting epithelial regeneration postinjury, thus representing an attractive therapeutic target for treating lung damage. Editor's summary: Respiratory virus infections can cause long-lasting lung damage, but how specific lung myeloid cell populations contribute to postinfection recovery is not fully understood. Using a mouse model of influenza A virus infection, Ruscitti et al. identified a distinct population of Ly6G+ monocyte-derived macrophages that emerges during the early recovery phase after viral-triggered lung injury. Ly6G+ lung macrophages were short lived and highly phagocytic and populated the alveoli within perilesional areas undergoing regeneration. Genetically engineered mice lacking lung Ly6G+ macrophages displayed impaired epithelial regeneration after influenza infection. Together, these findings identify a previously unappreciated population of reparative lung macrophages that could be targeted therapeutically to treat lung damage. —Claire Olingy [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |