التفاصيل البيبلوغرافية
| العنوان: |
Impacts of Interleukin-10 Promoter Genotypes on Prostate Cancer. |
| المؤلفون: |
Chin, Yu-Ting, Tsai, Chung-Lin, Ma, Hung-Huan, Cheng, Da-Chuan, Tsai, Chia-Wen, Wang, Yun-Chi, Shih, Hou-Yu, Chang, Shu-Yu, Gu, Jian, Chang, Wen-Shin, Bau, Da-Tian |
| المصدر: |
Life (2075-1729); Aug2024, Vol. 14 Issue 8, p1035, 14p |
| مصطلحات موضوعية: |
SINGLE nucleotide polymorphisms, INTERLEUKIN-10, PROSTATE cancer, ODDS ratio, GENOTYPES |
| مستخلص: |
Prostate cancer (PCa) is a multifactorial disease influenced by genetic, environmental, and immunological factors. Genetic polymorphisms in the interleukin-10 (IL-10) gene have been implicated in PCa susceptibility, development, and progression. This study aims to assess the contributions of three IL-10 promoter single nucleotide polymorphisms (SNPs), A-1082G (rs1800896), T-819C (rs3021097), and A-592C (rs1800872), to the risk of PCa in Taiwan. The three IL-10 genotypes were determined using PCR-RFLP methodology and were evaluated for their contributions to PCa risk among 218 PCa patients and 436 non-PCa controls. None of the three IL-10 SNPs were significantly associated with the risks of PCa (p all > 0.05) in the overall analyses. However, the GG at rs1800896 combined with smoking behavior was found to significantly increase the risk of PCa by 3.90-fold (95% confidence interval [95% CI] = 1.28–11.89, p = 0.0231). In addition, the rs1800896 AG and GGs were found to be correlated with the late stages of PCa (odds ratio [OR] = 1.90 and 6.42, 95% CI = 1.05–3.45 and 2.30–17.89, p = 0.0452 and 0.0003, respectively). The IL-10 promoter SNP, A-1082G (rs1800896), might be a risk factor for PCa development among smokers and those at late stages of the disease. These findings should be validated in larger and more diverse populations. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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