التفاصيل البيبلوغرافية
| العنوان: |
Exploring LGR5 as a prognostic marker of extrahepatic cholangiocarcinoma: insights from expression analysis and clinical correlations. |
| المؤلفون: |
Tamada, Hisashi, Uehara, Takeshi, Yoshizawa, Takahiro, Iwaya, Mai, Asaka, Shiho, Nakajima, Tomoyuki, Kamakura, Masato, Ota, Hiroyoshi |
| المصدر: |
Diagnostic Pathology; 8/28/2024, Vol. 19 Issue 1, p1-7, 7p |
| مصطلحات موضوعية: |
NUCLEIC acid hybridization, GENE expression, CANCER stem cells, IN situ hybridization, OVERALL survival |
| مستخلص: |
Background: Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) is a cancer stem cell (CSC) marker of colorectal cancer and may be a CSC marker of other cancer types. Few studies have been conducted on LGR5 expression in extrahepatic cholangiocarcinoma (ECC). Methods: We analyzed LGR5 expression using RNAscope, a highly sensitive RNA in situ hybridization technique. Fifty-three ECCs were selected from the medical archives at Shinshu University Hospital and analyzed using a tissue microarray. LGR5 expression levels were divided into expression and no expression groups. LGR5 expression and clinicopathological characteristics were analyzed. Results: Among 25 cases, no LGR5-positive dots were identified. Among 28 cases, some LGR5-positive dots were observed in carcinoma cells, together with a wide range of LGR5-positive cells. LGR5 expression was conspicuous in glandular duct formations. Well- to moderately differentiated types showed significantly higher LGR5 expression than the poorly differentiated type (p = 0.0268). LGR5 expression was associated with good overall survival (p = 0.0219) and good disease-free survival (DFS) (p = 0.0228). High LGR5 expression was associated with well- to moderately-differentiated types, indicating a favorable prognosis. In terms of DFS, multivariate analysis showed that high LGR5 expression was an independent favorable prognostic factor (p = 0.0397). Conclusions: These findings suggest that LGR5 is a promising, novel prognostic marker. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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