التفاصيل البيبلوغرافية
| العنوان: |
Bilirubin Nanoparticles Alleviate Sepsis-Induced Acute Lung Injury by Protecting Pulmonary Endothelia Glycocalyx and Reducing Inflammation. |
| المؤلفون: |
Xia, Xing, Sun, Tuyue, Zhao, Yingyi, Sheng, Huixiang, Dong, Xuan, Cheng, Yang, Wu, Fugen, Kou, Longfa, Chen, Ruijie, Yao, Qing, Zhang, Hailin |
| المصدر: |
ACS Applied Nano Materials; 8/23/2024, Vol. 7 Issue 16, p18566-18578, 13p |
| مستخلص: |
Acute lung injury (ALI) remains one of the most common complications of sepsis. Although many potential effective pharmacologic and ventilatory treatment strategies have been reported, there is still a lack of effective means of treatment of sepsis-induced ALI in the clinic. The aim of this study is to develop an easy-made endogenous bilirubin nanoparticle (BRNP) that could treat sepsis-induced ALI and investigate its underlying therapeutic mechanism. We prepared BRNP by bilirubin (BR) self-assembly and bovine serum albumin (BSA) coating with a simple one-pot nanoprecipitation method. BRNP holds good physical stability and could release BR in a sustained manner in a neutral medium but initiate a burst release in either acidic or oxidative conditions. In a sepsis murine model, BRNP could substantially alleviate the sepsis-induced lung injury, as evidenced by reduced histopathological changes of lung tissues and also reduced inflammation development. Mechanically, BRNP could alleviate the glycocalyx damage, inhibit the NF-κB pathway, and reduce proinflammatory factor release in vivo. This study provides a simple and robust BRNP to treat sepsis-induced ALI, which may pave the way to design multifunctional nanomedicine for clinical translation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |