التفاصيل البيبلوغرافية
| العنوان: |
Effect of inferior caval valve implantation on circulating immune cells and inflammatory mediators in severe tricuspid regurgitation. |
| المؤلفون: |
Mattig, Isabel, Hewing, Bernd, Knebel, Fabian, Meisel, Christian, Ludwig, Antje, Konietschke, Frank, Stangl, Verena, Stangl, Karl, Laule, Michael, Dreger, Henryk |
| المصدر: |
BMC Cardiovascular Disorders; 7/18/2024, Vol. 24 Issue 1, p1-10, 10p |
| مصطلحات موضوعية: |
INFLAMMATORY mediators, KILLER cells, VENA cava inferior, TUMOR necrosis factors, CYTOTOXIC T cells, TRICUSPID valve insufficiency |
| مستخلص: |
Background: Interventional valve implantation into the inferior vena cava (CAVI) lowers venous congestion in patients with tricuspid regurgitation (TR). We evaluated the impact of a reduction of abdominal venous congestion following CAVI on circulating immune cells and inflammatory mediators. Methods: Patients with severe TR were randomized to optimal medical therapy (OMT) + CAVI (n = 8) or OMT (n = 10). In the OMT + CAVI group, an Edwards Sapien XT valve was implanted into the inferior vena cava. Immune cells and inflammatory mediators were measured in the peripheral blood at baseline and three-month follow-up. Results: Leukocytes, monocytes, basophils, eosinophils, neutrophils, lymphocytes, B, T and natural killer cells and inflammatory markers (C-reactive protein, interferon-gamma, interleukin-2, -4, -5, -10, and tumor necrosis factor-alpha) did not change substantially between baseline and three-month follow-up within the OMT + CAVI and OMT group. Conclusion: The present data suggest that reduction of venous congestion following OMT + CAVI may not lead to substantial changes in systemic inflammation within a short-term follow-up. Clinical trial registration: NCT02387697 [ABSTRACT FROM AUTHOR] |
|
Copyright of BMC Cardiovascular Disorders is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder