التفاصيل البيبلوغرافية
| العنوان: |
Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis. |
| المؤلفون: |
Thompson, Emma J., Escarbe, Samantha, Tvorogov, Denis, Farshid, Gelareh, Gregory, Philip A., Khew-Goodall, Yeesim, Madden, Stephen, Ingman, Wendy V., Lindeman, Geoffrey J., Lim, Elgene, Lopez, Angel F., Bonder, Claudine S. |
| المصدر: |
Growth Factors; May2024, Vol. 42 Issue 2, p49-61, 13p |
| مصطلحات موضوعية: |
TRIPLE-negative breast cancer, MOLECULAR pathology, PROGESTERONE receptors, BREAST cancer, INTERLEUKIN-3, EPIDERMAL growth factor receptors, ESTROGEN receptors |
| مستخلص: |
Breast cancer represents a collection of pathologies with different molecular subtypes, histopathology, risk factors, clinical behavior, and responses to treatment. "Basal-like" breast cancers predominantly lack the receptors for estrogen and progesterone (ER/PR), lack amplification of human epidermal growth factor receptor 2 (HER2) but account for 10–15% of all breast cancers, are largely insensitive to targeted treatment and represent a disproportionate number of metastatic cases and deaths. Analysis of interleukin (IL)-3 and the IL-3 receptor subunits (IL-3RA + CSF2RB) reveals elevated expression in predominantly the basal-like group. Further analysis suggests that IL-3 itself, but not the IL-3 receptor subunits, associates with poor patient outcome. Histology on patient-derived xenografts supports the notion that breast cancer cells are a significant source of IL-3 that may promote disease progression. Taken together, these observations suggest that IL-3 may be a useful marker in solid tumors, particularly triple negative breast cancer, and warrants further investigation into its contribution to disease pathogenesis. [ABSTRACT FROM AUTHOR] |
|
Copyright of Growth Factors is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |