التفاصيل البيبلوغرافية
| العنوان: |
New 1,1-dibenzyl-3-(1-benzyl-1H-pyrazol-4-yl)-2-methylisothioureas: synthesis and evaluation of antioxidant activity. |
| المؤلفون: |
Proshin, A. N., Trofimova, T. P., Globa, A. A., Dubrovskaya, E. S., Zefirova, O. N., Zefirov, N. A., Tafeenko, V. A., Dutova, T. Ya., Ugrak, B. I., Serkov, I. V. |
| المصدر: |
Russian Chemical Bulletin; May2024, Vol. 73 Issue 5, p1399-1407, 9p |
| مصطلحات موضوعية: |
GLUTAMATE receptors, DIBENAMINE, THIOUREA, ANTIOXIDANTS, METHYL aspartate receptors, HYDROGEN peroxide, NEUROBLASTOMA |
| مستخلص: |
1,1-Dibenzyl-3-(1-benzyl-1 1H-pyrazol-4-yl)-2-methylisothioureas containing structural elements both of known antioxidants and glutamate receptor modulators were proposed as compounds with a dual mode of biological action, namely the antioxidant activity and the ability to influence the glutamatergic signaling system. The target compounds were synthesized by the reaction of substituted 4-amino-1-benzylpyrazoles with thiophosgene followed by the condensation of the resulting 1-benzyl-4-isothiocyanato-1H-pyrazoles with dibenzylamine and the subsequent S-methylation of the resulting thioureas. 1,1-Dibenzyl-3-[1-(3,4-dichlorobenzyl)- and 1,1-dibenzyl-3-[1-(2,4-dichlorobenzyl)-1H-pyrazol-4-yl]-2-methylisothioureas were found to have a moderate ability to protect neuroblastoma cells against the toxic effect of hydrogen peroxide, making these compounds interesting for further study of the modulatory activity toward glutamate receptors. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |