التفاصيل البيبلوغرافية
| العنوان: |
Early initiation of combined therapy in severely immunocompromised patients with COVID-19: a retrospective cohort study. |
| المؤلفون: |
Rotundo, Salvatore, Berardelli, Lavinia, Gullì, Sara, La Gamba, Valentina, Lionello, Rosaria, Russo, Alessandro, Trecarichi, Enrico Maria, Torti, Carlo |
| المصدر: |
BMC Infectious Diseases; 6/6/2024, Vol. 24 Issue 1, p1-7, 7p |
| مصطلحات موضوعية: |
COVID-19, IMMUNOCOMPROMISED patients, COHORT analysis, VIRAL shedding, RETROSPECTIVE studies |
| مستخلص: |
This single-centre retrospective cohort study reports on the results of a descriptive (non-comparative) retrospective cohort study of early initiation of antivirals and combined monoclonal antibody therapy (mAbs) in 48 severely immunocompromised patients with COVID-19. The study assessed the outcomes and the duration of viral shedding. The patients started early combined therapy (ECT) a median of 2 days (interquartile range [IQR]: 1–3 days) after the diagnosis of SARS-CoV-2 infection. Except for 1 patient who died due COVID-19-related respiratory failure, patients had their first negative nasopharyngeal swab result after a median of 11 days (IQR: 6–17 days) after starting combined therapy. There were no reports of severe side effects. During a follow-up period of 512 days (interquartile range [IQR]: 413–575 days), 6 patients (12.5%) died and 16 (33.3%) were admitted to hospital. Moreover, 12 patients (25%) were diagnosed with SARS-CoV-2 reinfection a median of 245 days (IQR: 138–401 days) after starting combined treatment. No relapses were reported. Although there was no comparison group, these results compare favourably with the outcomes of severely immunocompromised patients with COVID-19 reported in the literature. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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