التفاصيل البيبلوغرافية
| العنوان: |
Tea polyphenols combined with Lactobacillus rhamnosus R5 ameliorate obesity, and alter gut microbiota composition in high-fat-diet-fed mice. |
| المؤلفون: |
Liu, M. D., Wang, W. J., Lv, Q. Y., Xiao, J., Xu, Q. S., Jiao, S. R. |
| المصدر: |
International Food Research Journal; Feb2024, Vol. 31 Issue 1, p203-214, 12p |
| مصطلحات موضوعية: |
LACTOBACILLUS rhamnosus, GUT microbiome, PROBIOTICS, LDL cholesterol, HDL cholesterol, POLYPHENOLS |
| مستخلص: |
Both tea polyphenols (TP) and Lactobacillus rhamnosus have been shown to alleviate obesity, and regulate lipid metabolism. However, the combined effects and their underlying mechanisms of action remain elusive. In the present work, the effects of TP, Lactobacillus rhamnosus R5 (R5), and TP+R5 on blood lipids and the gut microbiota of mice fed with a high-fat diet were compared. Results showed that the combination of TP and R5 effectively increased the serum levels of high-density lipoprotein cholesterol (HDL-C), and decreased total cholesterol (TC) levels, low-density lipoprotein cholesterol (LDL-C) levels, and the atherosclerosis index (AI) in mice fed with a high-fat diet. The combination treatment resulted in a modification of the structure of the gut microbiota in mice, as evidenced by a decrease in the F/B ratio, and an increase in the abundance of beneficial genera, such as Akkermansia muciniphila, Faecalibaculum rodentium, and Ruminococcus_uncultured bacterium. Additionally, the contents of SCFAs (acetic, propionic, and butyric acids) in faeces also increased. These could provide new ideas for anti-obesity methods, and a theoretical basis for the development of foods combining probiotics and tea polyphenols. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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