التفاصيل البيبلوغرافية
| العنوان: |
Major complications after intraoperative radiotherapy with low-energy x-rays in early breast cancer. |
| المؤلفون: |
Berger, Laura, Grimm, Anja, Sütterlin, Marc, Spaich, Saskia, Sperk, Elena, Tuschy, Benjamin, Berlit, Sebastian |
| المصدر: |
Strahlentherapie und Onkologie; Apr2024, Vol. 200 Issue 4, p276-286, 11p |
| مستخلص: |
Purpose: To describe and analyze major local complications after intraoperative radiotherapy (IORT) with low-energy x‑rays during breast-conserving surgery (BCS) in early breast cancer. Methods: Ten women out of 408 who were treated with IORT between 2002 and 2017 and subsequently developed a severe local complication requiring surgical intervention were retrospectively identified and analyzed. Demographic, clinical, and surgical parameters as well as complication characteristics and treatment methods were evaluated. Results: At initial presentation, eight patients (80%) showed redness, six (60%) seroma, six (60%) wound infection, six (60%) suture dehiscence, and four (40%) induration of the former surgical area. Hematoma and necrosis were observed in one case (10%) each. Time interval until appearance of the first symptoms ranged from directly postoperative until 15 years postoperatively (median 3.1 months). Initial treatment modalities comprised antibiotic therapy (n = 8/80%) and transcutaneous aspiration of seroma (n = 3/30%). In the majority of patients, smaller surgical interventions (excision of a necrotic area/fistula [n = 6/60%] or secondary suture [n = 5/50%]) were sufficient to overcome the complication, yet larger interventions such as complex flap surgery and mastectomy were necessary in one patient each. Conclusion: IORT is an efficient and safe treatment method as < 2.5% of all IORT patients experienced major local complications. However, it seems to pose the risk of causing severe local complications that may require lengthy and burdensome treatment. Thorough preoperative counseling, implementation of recommended intraoperative precautions, and high vigilance for first symptoms of complications during follow-up appointments are necessary measures. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |