التفاصيل البيبلوغرافية
| العنوان: |
牡丹雄蕊对慢性非细菌性前列腺炎 大鼠模型的影响. (Chinese) |
| Alternate Title: |
Effect of Paeonia suffruticosa Andr. Stamens on Rat Model of Chronic Abacterial Prostatitis. (English) |
| المؤلفون: |
程丹丹, 高德民, 王岱杰, 梁 栋, 庞志勇, 徐亚振, 王惠敏, 袁文鹏 |
| المصدر: |
Science & Technology of Food Industry; Jan2024, Vol. 45 Issue 2, p342-348, 7p |
| مصطلحات موضوعية: |
TREE peony, ESTRADIOL benzoate, STAMEN, PROSTATITIS |
| Abstract (English): |
In order to investigate the pharmacological effect of Paeonia suffruticosa Andr. stamens on chronic non-bacterial prostatitis (CNBP) in rats, the rats with chronic abacterial prostatitis induced by castration combined subcutaneous injection of hormone (estradiol benzoate 0.25 mg·kg-1) were used as models. Forty rats with CNBP were randomly divided into five groups (8 per group): Model group (normal saline), positive group (celecoxib 250 mg·kg-1), various doses of lyophilized powder of Paeonia suffruticosa Andr. stamens groups (100, 200, 400 mg·kg-1). Another group of normal mice treated with normal saline as normal group. The therapeutic effect of Paeonia suffruticosa Andr. stamens on CNBP was evaluated by lecithin body density, prostatic index, cytokines in prostate tissue and the expression levels of TXB2 and 6-K-PGF1α in blood. The results showed that the inflammation of prostate tissue in rats was significantly improved. Compared with model group, the number of white blood cells, prostate weight, prostate index, TXB2 and the content of PGE2 in prostate tissue of rats were significantly decreased in each dosage group of Paeonia suffruticosa Andr. stamens (P<0.01, P<0.05). The contents of ICAM-1, INF-γ, TNF-α, MCP-1 and IL-8 in high-dose group of Paeonia suffruticosa Andr. stamens were significantly decreased (P<0.01, P<0.05), and in low-dose group were also decreased, but there was no significant difference (P>0.05). The contents of 6-keto-PGF1α and NO in high dose of Paeonia suffruticosa Andr. stamens were significantly increased (P<0.01, P<0.05), and in low dose group were also increased, but there was no significant difference (P>0.05). This study showed that Paeonia suffruticosa Andr. stamens had therapeutic effect on chronic abacterial prostatitis, which would provide a theoretical basis for further development and application of the Paeonia suffruticosa Andr. stamens. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
为探究牡丹雄蕊对大鼠慢性非细菌性前列腺炎的药理作用。实验以去势+皮下注射激素（苯甲酸雌二醇 0.25 mg·kg-1）诱导的慢性非细菌性前列腺炎大鼠为动物模型。将40 只非细菌性前列腺炎模型大鼠随机分成5 组 （每组8 只）;模型组、阳性组（塞来昔布250 mg·kg-1）和牡丹雄蕊低、中、高剂量组（100、200、400 mg·kg-1）。 另外选取等量生理盐水处理的正常大鼠作为空白对照组。以大鼠卵磷脂小体密度、前列腺指数及前列腺组织中细 胞因子及血液中TXB2 和6-K-PGF1α 的表达水平为评价指标，评价牡丹雄蕊对慢性非细菌性前列腺炎的治疗作 用。实验结果显示大鼠前列腺组织炎症病变程度明显改善，与模型组比较牡丹雄蕊各剂量组白细胞数目、大鼠前 列腺重、前列腺指数、TXB2 以及大鼠前列腺组织中PGE2 的含量均明显降低（P<0.01，P<0.05）；牡丹雄蕊高剂 量组ICAM-1、INF-γ、TNF-α、MCP-1 以及IL-8 的含量显著降低（P<0.01，P<0.05），低剂量组也均有下降，但 无显著差异（P>0.05）；牡丹雄蕊高剂量中6-keto-PGF1α 及NO 的含量显著升高（P<0.01，P<0.05），低剂量组 也均有升高，但无差异差异（P>0.05）。本研究表明牡丹雄蕊对慢性非细菌性前列腺炎具有治疗作用，为牡丹雄 蕊的进一步开发应用提供了理论依据. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |