التفاصيل البيبلوغرافية
| العنوان: |
Chili pepper extracts, capsaicin, and dihydrocapsaicin as potential anticancer agents targeting topoisomerases. |
| المؤلفون: |
Hudáková, Terézia, Šemeláková, Martina, Očenáš, Peter, Kožurková, Mária, Krochtová, Kristína, Sovová, Simona, Tóthová, Zuzana, Guľášová, Zuzana, Popelka, Peter, Solár, Peter |
| المصدر: |
BMC Complementary Medicine & Therapies; 2/21/2024, Vol. 24 Issue 1, p1-11, 11p |
| مصطلحات موضوعية: |
COLON tumors, PILOT projects, IN vitro studies, HIGH performance liquid chromatography, ONE-way analysis of variance, ANTINEOPLASTIC agents, CELL proliferation, DESCRIPTIVE statistics, TOXICITY testing, PLANT extracts, DNA damage, CELL lines, DATA analysis software, CAPSAICIN, HOT peppers, ENZYME inhibitors, PHARMACODYNAMICS |
| مستخلص: |
DNA topoisomerases regulate conformational changes in DNA topology during normal cell growth, such as replication, transcription, recombination, and repair, and may be targeted for anticancer drugs. A DNA topology assay was used to investigate DNA-damaging/protective activities of extracts from Habanero Red (HR), Habanero Maya Red (HMR), Trinidad Moruga Scorpion (TMS), Jalapeno (J), Serrano pepper (SP), Habanero Red Savina (HRS), Bhut Jolokia (BJ), and Jamaica Rosso (JR) peppers, demonstrating their inhibitory effect on the relaxation of pBR by Topo I. DNA topoisomerase II (Topo II) is proven therapeutic target of anticancer drugs. Complete inhibition of Topo II was observed for samples TMS, HR, and HMR. Extracts J and SP had the lowest capsaicin and dihydrocapsaicin content compared to other peppers. HR, HMR, TMS, J, S, HRS, BJ, JR extracts showed the anticancer effect, examined by MTS and xCell assay on the in vitro culture of human colon carcinoma cell line HCT116. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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