التفاصيل البيبلوغرافية
| العنوان: |
Oral antimicrobial therapy for cellulitis versus outpatient parenteral antimicrobial therapy: a single‐centre audit of cellulitis outcomes. |
| المؤلفون: |
Bowhay, Thomas R., Tsang, Tiffany, Wei, Jeremy C. Z., Edwik, Wafa, Fridman, Avi, Hubber, Julia, Jo, Jae Y., Mckay, Nicole, O'Brien, Catherine, Osmond‐Wallam, Joe, Smythe, James, Crump, John A., Arnold, Brendan |
| المصدر: |
Internal Medicine Journal; Feb2024, Vol. 54 Issue 2, p320-327, 8p |
| مصطلحات موضوعية: |
CLINICAL drug trials, BETA lactam antibiotics, GENERIC drug substitution, ORAL drug administration, PROBENECID (Drug), CELLULITIS, ANTI-infective agents, RETROSPECTIVE studies, PARENTERAL infusions, CEFAZOLIN, TREATMENT effectiveness, COMPARATIVE studies, DESCRIPTIVE statistics, ODDS ratio, PATIENT compliance, EVALUATION |
| مصطلحات جغرافية: |
NEW Zealand |
| مستخلص: |
Background: Cellulitis is a common acute skin and soft tissue infection that causes substantial morbidity and healthcare costs. Aims: To audit the impact on cellulitis management, regimen tolerability and outcomes of switching from outpatient parenteral antimicrobial therapy (OPAT) using intravenous (i.v.) cefazolin once daily plus probenecid to oral beta‐lactam therapy (OBLT) using oral flucloxacillin plus probenecid. Methods: We undertook a retrospective audit on cellulitis management, regimen tolerability and outcomes at the Dunedin Public Hospital Emergency Department (ED) before and after a change of the local outpatient cellulitis treatment pathway from OPAT using i.v. cefazolin once daily plus probenecid to OBLT using oral flucloxacillin plus probenecid. Results: OPAT was used in 97/123 (78.9%) patients with cellulitis before compared to 1/70 (1.4%) after the pathway change (odds ratio (OR), 0.04, P < 0.01). OBLT was used in 26/123 (21.1%) patients with cellulitis before and 69/70 (98.6%) after (OR, 218.8, P < 0.01). Antimicrobial change due to intolerance occurred in 4/123 (3.2%) patients with cellulitis before and 4/70 (5.7%) after (OR, 1.8, P, not significant (NS)) the pathway change. Inpatient admission within 28 days occurred in 15/123 (12.2%) cellulitis patients before and 9/70 (12.9%) after (OR, 1.1, P, NS) the pathway change. Conclusions: Implementation of a change in outpatient cellulitis treatment pathway resulted in a significant change in prescribing practice. Our findings suggest that OBLT was both tolerable and had similar outcomes to OPAT. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |