التفاصيل البيبلوغرافية
| العنوان: |
Comparisons of Pediatric and Adult SARS-CoV-2-Specific Antibodies up to 6 Months after Infection, Vaccination, or Hybrid Immunity. |
| المؤلفون: |
Kim, Minjun, Cheng, Wesley A, Congrave-Wilson, Zion, Ruiz, Carolyn Jennifer Marentes, Turner, Lauren, Mendieta, Shirley, Jumarang, Jaycee, Valle, Jennifer Del, Lee, Yesun, Fabrizio, Thomas, Allen, E Kaitlynn, Thomas, Paul G, Webby, Richard, Gordon, Aubree, Pannaraj, Pia S |
| المصدر: |
Journal of the Pediatric Infectious Diseases Society; Jan2024, Vol. 13 Issue 1, p91-99, 9p |
| مصطلحات موضوعية: |
COVID-19, SARS-CoV-2, IMMUNOGLOBULINS, CONFIDENCE intervals, COVID-19 vaccines, SERODIAGNOSIS, COMPARATIVE studies, IMMUNITY, NEUTRALIZATION tests, ENZYME-linked immunosorbent assay, RESEARCH funding, DESCRIPTIVE statistics, VACCINATION status, RECEIVER operating characteristic curves |
| مستخلص: |
Background Characterization of longitudinal SARS-CoV-2-specific antibody responses in children following infection and vaccination is needed to inform SARS-CoV-2 vaccine policy decisions for children, which may differ from adults. Methods We enrolled individuals at the time of SARS-CoV-2 infection or vaccination for longitudinal serological testing and compared SARS-CoV-2-spike-specific IgG and neutralization activity in children and adults stratified by infection and vaccination status using enzyme-linked immunosorbent and virus neutralization assays. Results Between June 2020 and December 2022, we collected sera from 669 participants aged 40 days to 55 years, including 330 unvaccinated individuals with laboratory-confirmed SARS-CoV-2 infection, 180 vaccinated SARS-CoV-2-naïve individuals, and 159 vaccinated previously infected individuals. Half (n = 330, 49.3%) were children. SARS-CoV-2-specific IgG and neutralization activity in children < 12 years old in response to infection persisted at higher levels than those of adults through at least 6 months (spike-specific IgG levels, 2.05 [95% CI: 1.4-3.1] times higher than adults; neutralizing activity, median 88.8 vs 75.2%, respectively, p = .04). In addition, all pediatric participants had significantly higher IgG levels compared with adults at 6 months following infection or vaccination, regardless of prior infection status. Vaccine-induced SARS-CoV-2-specific IgG responses in previously infected individuals persisted at higher levels than those from infection alone at 6 months (median AUC, children 5-11 years old, 9115 vs 368; adolescents 3613 vs 475; adults 1956 vs 263, all p < .001). Conclusions These data demonstrate the robust and persistent immunologic response of SARS-CoV-2 vaccination in children and emphasize the benefit of vaccination after SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of the Pediatric Infectious Diseases Society is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder