التفاصيل البيبلوغرافية
| العنوان: |
Temporal-spatial Generation of Astrocytes in the Developing Diencephalon. |
| المؤلفون: |
Hong, Wentong, Gong, Pifang, Pan, Xinjie, Ren, Zhonggan, Liu, Yitong, Qi, Guibo, Li, Jun-Liszt, Sun, Wenzhi, Ge, Woo-Ping, Zhang, Chun-Li, Duan, Shumin, Qin, Song |
| المصدر: |
Neuroscience Bulletin; Jan2024, Vol. 40 Issue 1, p1-16, 16p |
| مستخلص: |
Astrocytes are the largest glial population in the mammalian brain. However, we have a minimal understanding of astrocyte development, especially fate specification in different regions of the brain. Through lineage tracing of the progenitors of the third ventricle (3V) wall via in-utero electroporation in the embryonic mouse brain, we show the fate specification and migration pattern of astrocytes derived from radial glia along the 3V wall. Unexpectedly, radial glia located in different regions along the 3V wall of the diencephalon produce distinct cell types: radial glia in the upper region produce astrocytes and those in the lower region produce neurons in the diencephalon. With genetic fate mapping analysis, we reveal that the first population of astrocytes appears along the zona incerta in the diencephalon. Astrogenesis occurs at an early time point in the dorsal region relative to that in the ventral region of the developing diencephalon. With transcriptomic analysis of the region-specific 3V wall and lateral ventricle (LV) wall, we identified cohorts of differentially-expressed genes in the dorsal 3V wall compared to the ventral 3V wall and LV wall that may regulate astrogenesis in the dorsal diencephalon. Together, these results demonstrate that the generation of astrocytes shows a spatiotemporal pattern in the developing mouse diencephalon. [ABSTRACT FROM AUTHOR] |
|
Copyright of Neuroscience Bulletin is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder