التفاصيل البيبلوغرافية
| العنوان: |
Complement activation by eggs and microfilariae of filarial parasites. |
| المؤلفون: |
Rao, U. R., Chandrashekar, R., Subrahmanyam, D. |
| المصدر: |
Immunology & Cell Biology; Oct1987, Vol. 65 Issue 5, p365-370, 6p |
| مصطلحات موضوعية: |
FILARIAL worms, LITOMOSOIDES carinii, SPIRURIDA, PARASITES, LABORATORY rats, FILARIIDAE |
| مستخلص: |
The complement of fresh normal rat serum was activated by filarial eggs and microfilariae (mf). C3 was deposited on the surface of Litomosoides carinii, Brugia pahangi, Brugia malayi and Dipetalonema viteae as seen by immunofluorescence. Inira-uterine and in vitro-derived mf did not bind C3. In contrast, C3 bound to the blood-derived mf of B. pahangi and B. malayi as well as exsheathed mf of L. carinii and B. malay. Significant consumption of complement was observed with eggs of all filarial species, as well as sheathed mf of B. pahangi, B. malayi and exsheathed mf of L. carinii and B. malayi. These experiments indicated that complement was activated by filarial parasites via the alternative pathway. The bound complement promoted neutrophil-mediated adherence and cytotoxicity. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |