التفاصيل البيبلوغرافية
| العنوان: |
Synthesis, radiolabeling and in vitro evaluation of azathioprine loaded magnetic solid lipid nanoparticles. |
| المؤلفون: |
Türkkanı, Gökce, Güngör, Burcu, Cetin, Oğuz, İçhedef, Çiğdem, Parlak, Yasemin, Gümüşer, F. Gül, Sayıt Bilgin, B. Elvan, Teksöz, Serap |
| المصدر: |
Journal of Radioanalytical & Nuclear Chemistry; Nov2023, Vol. 332 Issue 11, p4695-4704, 10p |
| مصطلحات موضوعية: |
TARGETED drug delivery, RADIOLABELING, DRUG delivery systems, AZATHIOPRINE, LIPIDS, NANOPARTICLES |
| مستخلص: |
In this study, it is aimed to design a smart drug delivery system for the diagnosis and treatment of cancer cells. Magnetic-solid lipid nanoparticles were synthesized as a drug delivery system and azathioprine (AZA) was loaded into this system. This newly created system was radiolabeled using technetium-99 m with a radiolabeling yield of 90.3%. Drug loading into the SLMNP was found as 86%. The biological behavior of 99mTc and radiolabeled magnetic solid lipid nanoparticles loaded with azathioprine (99mTc-AZA-SLMNP) was investigated in vitro and in vivo. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Radioanalytical & Nuclear Chemistry is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |