Academic Journal

The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases?

التفاصيل البيبلوغرافية
العنوان: The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases?
المؤلفون: Kohil, Amira, Abdalla, Wafa, Ibrahim, Wisam N., Al-Harbi, Khalid M., Al-Haidose, Amal, Al-Asmakh, Maha, Abdallah, Atiyeh M.
المصدر: Medicina (1010660X); Sep2023, Vol. 59 Issue 9, p1629, 15p
مصطلحات موضوعية: RHEUMATIC heart disease, RHEUMATISM, RHEUMATIC fever, MOLECULAR mimicry, GUT microbiome, IMMUNOLOGICAL tolerance
مستخلص: Rheumatic heart disease (RHD) represents a serious cardiac sequela of acute rheumatic fever, occurring in 30–45% of patients. RHD is multifactorial, with a strong familial predisposition and known environmental risk factors that drive loss of immunological tolerance. The gut and oral microbiome have recently been implicated in the pathogenesis of RHD. Disruption of the delicate balance of the microbiome, or dysbiosis, is thought to lead to autoimmune responses through several different mechanisms including molecular mimicry, epitope spreading, and bystander activation. However, data on the microbiomes of RHD patients are scarce. Therefore, in this comprehensive review, we explore the various dimensions of the intricate relationship between the microbiome and the immune system in RHD and other rheumatic diseases to explore the potential effect of microbiota on RHD and opportunities for diagnosis and treatment. [ABSTRACT FROM AUTHOR]
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قاعدة البيانات: Complementary Index
الوصف
تدمد:1010660X
DOI:10.3390/medicina59091629