التفاصيل البيبلوغرافية
| العنوان: |
Pirfenidone ameliorates liver steatosis by targeting the STAT3-SCD1 axis. |
| المؤلفون: |
Yang, Shan, Zhang, Renzi, Deng, Wenzhen, Chang, Shichuan, Li, Yang, Li, Sheng |
| المصدر: |
Inflammation Research; Sep2023, Vol. 72 Issue 9, p1773-1787, 15p |
| مصطلحات موضوعية: |
FATTY liver, FATTY degeneration, FREE fatty acids, HIGH-fat diet, LIVER |
| مستخلص: |
Objective: Previous studies reported that pirfenidone (PFD) is associated with liver disease. However, the effects of pirfenidone on energy metabolism and hepatic lipid accumulation are still poorly understood. Methods: In this study, C57BL/6J mice were randomly divided into two groups, and fed a normal chow diet (NCD) or a high-fat diet (HFD) for 16 weeks. At the end of the eighth week, half of the mice fed on both diets were treated with PFD. Biochemical and lipid metabolism-related indices were analyzed. Furthermore, Hepa 1–6 cells and mouse primary hepatocytes (MPHs) were incubated with PFD with or without free fatty acid (FFA) treatment. Then, stattic (a p-STAT3 inhibitor) or Ad-shSTAT3 was used to further elucidate the effects of Signal Transducer and Activator of Transcription 3 (STAT3) signaling on PFD regulation of hepatic steatosis. Results: PFD ameliorated obesity and hepatic lipid deposition in HFD mice by decreasing stearoyl-CoA desaturase 1 (SCD1) expression and upregulating p-STAT3 in the liver. In Hepa 1–6 cells and MPHs, PFD also down-regulated the expression of SCD1. STAT3 inhibition treatment eliminated the benefits of PFD on both SCD1 and hepatic steatosis. Conclusion: In summary, our data reveal that PFD may play an important role in mitigating hepatic steatosis in a STAT3-SCD1-dependent manner. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |