التفاصيل البيبلوغرافية
| العنوان: |
The Correlation of miR-671-5p with Diagnosis and Prognosis in Multiple Myeloma. |
| المؤلفون: |
Kuai Yu, Jiulong Li, Dingchuan Chen, Wenhui Huan |
| المصدر: |
Clinical Laboratory; 2023, Vol. 69 Issue 8, p1632-1639, 8p |
| مصطلحات موضوعية: |
MULTIPLE myeloma, PROGNOSIS, PROGRESSION-free survival, OVERALL survival, DIAGNOSIS, BONE marrow, EOSINOPHILIC granuloma |
| مستخلص: |
Background: This study aimed to investigate the value of miR-671-5p in multiple myeloma (MM) in diagnostics and prognosis and developed a potential biomarker to improve the prognosis of MM. Methods: Plasma cells were isolated from bone marrow samples of 80 MM patients, in which miR-671-5p levels were determined. The correlation between miR-671-5p expression with serum creatinine, β-2-microglobulin, lactate dehydrogenase, bone lesions, International Staging System staging, chromosomal abnormalities, and albumin was analyzed. The association between miR-671-5p expression with progression-free survival and overall survival in MM patients was determined. Results: miR-671-5p expression was reduced and predicted an increased risk of MM. miR-671-5p expression was negatively correlated with serum creatinine, β-2-microglobulin, lactate dehydrogenase, bone lesions, International Staging System staging, and chromosomal abnormalities, and positively correlated with albumin. miR-671-5p expression was augmented in complete response patients and overall response rate patients, and differentiated CR and ORR patients from Non-CR and Non-ORR patients. Furthermore, miR-671-5p low expression was associated with unfavorable progression-free survival and overall survival in MM patients. Conclusions: In a word, miR-671-5p is associated with worsening clinical properties, increased ISS staging, unfavorable chromosomal abnormalities, and poor prognosis in MM patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |