التفاصيل البيبلوغرافية
| العنوان: |
The cerebellum contributes to generalized seizures by altering activity in the ventral posteromedial nucleus. |
| المؤلفون: |
Beckinghausen, Jaclyn, Ortiz-Guzman, Joshua, Lin, Tao, Bachman, Benjamin, Salazar Leon, Luis E., Liu, Yu, Heck, Detlef H., Arenkiel, Benjamin R., Sillitoe, Roy V. |
| المصدر: |
Communications Biology; 7/15/2023, Vol. 6 Issue 1, p1-17, 17p |
| مصطلحات موضوعية: |
CEREBELLAR nuclei, SEIZURES (Medicine), CEREBELLUM, CEREBELLAR cortex, DEEP brain stimulation, LABORATORY mice, THALAMUS, THALAMIC nuclei |
| مستخلص: |
Thalamo-cortical networks are central to seizures, yet it is unclear how these circuits initiate seizures. We test whether a facial region of the thalamus, the ventral posteromedial nucleus (VPM), is a source of generalized, convulsive motor seizures and if convergent VPM input drives the behavior. To address this question, we devise an in vivo optogenetic mouse model to elicit convulsive motor seizures by driving these inputs and perform single-unit recordings during awake, convulsive seizures to define the local activity of thalamic neurons before, during, and after seizure onset. We find dynamic activity with biphasic properties, raising the possibility that heterogenous activity promotes seizures. Virus tracing identifies cerebellar and cerebral cortical afferents as robust contributors to the seizures. Of these inputs, only microinfusion of lidocaine into the cerebellar nuclei blocks seizure initiation. Our data reveal the VPM as a source of generalized convulsive seizures, with cerebellar input providing critical signals. Single-unit in vivo electrophysiology recordings performed in optogenetic-induced seizing mice and regional pharmacological drug ablation experiments show a role of cerebellar inputs to the thalamus in driving seizures [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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