التفاصيل البيبلوغرافية
| العنوان: |
Analysis of the Role of Stellate Cell VCAM-1 in NASH Models in Mice. |
| المؤلفون: |
Chung, Kyoung-Jin, Legaki, Aigli-Ioanna, Papadopoulos, Grigorios, Gercken, Bettina, Gebler, Janine, Schwabe, Robert F., Chavakis, Triantafyllos, Chatzigeorgiou, Antonios |
| المصدر: |
International Journal of Molecular Sciences; Mar2023, Vol. 24 Issue 5, p4813, 12p |
| مصطلحات موضوعية: |
VASCULAR cell adhesion molecule-1, NON-alcoholic fatty liver disease, LIVER cells, CELL adhesion molecules, LABORATORY mice |
| مستخلص: |
Non-alcoholic fatty liver disease (NAFLD) can progress to non-alcoholic steatohepatitis (NASH), characterized by inflammation and fibrosis. Fibrosis is mediated by hepatic stellate cells (HSC) and their differentiation into activated myofibroblasts; the latter process is also promoted by inflammation. Here we studied the role of the pro-inflammatory adhesion molecule vascular cell adhesion molecule-1 (VCAM-1) in HSCs in NASH. VCAM-1 expression was upregulated in the liver upon NASH induction, and VCAM-1 was found to be present on activated HSCs. We therefore utilized HSC-specific VCAM-1-deficient and appropriate control mice to explore the role of VCAM-1 on HSCs in NASH. However, HSC-specific VCAM-1-deficient mice, as compared to control mice, did not show a difference with regards to steatosis, inflammation and fibrosis in two different models of NASH. Hence, VCAM-1 on HSCs is dispensable for NASH development and progression in mice. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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