التفاصيل البيبلوغرافية
| العنوان: |
Ventilation Induces Changes in Pulse Wave Transit Time in the Pulmonary Artery. |
| المؤلفون: |
Mueller-Graf, Fabian, Frenkel, Paul, Albus, Chiara Felicitas, Henkel, Maike, Reuter, Susanne, Vollmar, Brigitte, Tusman, Gerardo, Adler, Andy, Pulletz, Sven, Böhm, Stephan H., Zitzmann, Amelie, Reuter, Daniel A. |
| المصدر: |
Biomedicines; Jan2023, Vol. 11 Issue 1, p182, 11p |
| مصطلحات موضوعية: |
PULMONARY artery, PULMONARY artery catheters, VENTILATION, EDIBLE fats & oils |
| مستخلص: |
Pulse wave transit time (PWTT) shortens as pulmonary artery pressure (PAP) increases and was therefore suggested as a surrogate parameter for PAP. The aim of this analysis was to reveal patterns and potential mechanisms of ventilation-induced periodic changes in PWTT under resting conditions. To measure both PWTT and PAP in five healthy pigs, two pulmonary artery Mikro-Tip™ catheters were inserted into the pulmonary vasculature: one with the tip placed in the pulmonary artery trunk, and a second one placed in a distal segment of the pulmonary artery. Animals received pressure-controlled mechanical ventilation. Ventilation-dependent changes were seen in both variables, PWTT and mean PAP; however, changes in PWTT were not synchronous with changes in PAP. Thus, plotting the value of PWTT for each heartbeat over the respective PAP revealed a characteristic hysteresis. At the beginning of inspiration, PAP rose while PWTT remained constant. During further inspiration, PWTT started to decrease rapidly as mPAP was about to reach its plateau. The same time course was observed during expiration: while mPAP approached its minimum, PWTT increased rapidly. During apnea this hysteresis disappeared. Thus, non-synchronous ventilation-induced changes in PWTT and PAP were found with inspiration causing a significant shortening of PWTT. Therefore, it is suggested that the respiratory cycle should be considered when using PWTT as a surrogate for PAP. [ABSTRACT FROM AUTHOR] |
|
Copyright of Biomedicines is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder