التفاصيل البيبلوغرافية
| العنوان: |
Pancreatic cancer: Cutaneous metastases, clinical descriptors and outcomes. |
| المؤلفون: |
Gu, Lilly, Mehta, Paras P., Rao, Devika, Rotemberg, Veronica, Capanu, Marinela, Chou, Joanne, Lin, Sabrina, Sigel, Carlie S., Busam, Klaus J., Boyce, Lindsay, Gordon, Allison, O'Reilly, Eileen M. |
| المصدر: |
Cancer Medicine; Jan2023, Vol. 12 Issue 1, p179-188, 10p |
| مصطلحات موضوعية: |
PANCREATIC cancer, METASTASIS, TREATMENT effectiveness, CHECKPOINT kinase 2, DIAGNOSIS |
| مستخلص: |
Background: Cutaneous metastases in pancreatic cancer (PC) are rare. Herein, we evaluate the clinical, genomic, and other descriptors of patients with PC and cutaneous metastases. Methods: Institutional databases were queried, and clinical history, demographics, PC cutaneous metastasis details, and overall survival (OS) from cutaneous metastasis diagnosis were abstracted. OS was estimated using Kaplan–Meier methods. Results: Forty patients were identified, and median age (Q1–Q3, IQR) of PC diagnosis was 66.0 (59.3–72.3, 12.9) years. Most patients had Stage IV disease at diagnosis (n = 26, 65%). The most common location of the primary tumor was the tail of the pancreas (n = 17, 43%). The most common cutaneous metastasis site was the abdomen (n = 31, 78%), with umbilical lesions occurring in 74% (n = 23) of abdominal lesions. The median OS (95% CI) was 11.4 months (7.0, 20.4). Twenty‐three patients had umbilical metastases (58%), and 17 patients had non‐umbilical metastases (43%). The median OS (95% CI) was 13.7 (7.0, 28.7) months in patients with umbilical metastases and 8.9 (4.1, Not reached) months in patients with non‐umbilical metastases (p = 0.1). Sixteen of 40 (40%) patients underwent somatic testing, and findings were consistent with known profiles. Germline testing in 12 (30%) patients identified pathogenic variants in patients: CHEK2, BRCA1, and ATM. Conclusion: Cutaneous metastases from PC most frequently arise from a pancreas tail primary site and most frequently occur in the umbilicus. Cutaneous metastases may generally be categorized as umbilical or non‐umbilical metastases. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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