التفاصيل البيبلوغرافية
| العنوان: |
The Neuroprotective Effect Associated with Echinops spinosus in an Acute Seizure Model Induced by Pentylenetetrazole. |
| المؤلفون: |
Alkhudhayri, Abdulsalam, Abdel Moneim, Ahmed E., Rizk, Sara, Bauomy, Amira A., Dkhil, Mohamed A. |
| المصدر: |
Neurochemical Research; Jan2023, Vol. 48 Issue 1, p273-283, 11p |
| مصطلحات موضوعية: |
SEIZURES (Medicine), GABA, NEUROPROTECTIVE agents, HERBAL medicine, CELL death, ADENOSINE triphosphatase |
| مستخلص: |
Echinops spinosus (ES) is a medicinal plant with a wide range of pharmacological and biological effects. It is a medicinal herb having a variety of therapeutic characteristics, including antioxidant, anti-inflammatory, and antibacterial capabilities. The primary goal of this research is to investigate the neuroprotective and anticonvulsant characteristics of E. spinosa extract (ESE) against pentylenetetrazole (PTZ)-induced acute seizures. Negative control rats, ESE treatment rats, PTZ acute seizure model rats, ESE + PTZ rats, and Diazepam + PTZ rats were used in the study. The rats were given a 7-day treatment. ESE pretreatment elevated the latency to seizure onset and lowered seizure duration after PTZ injection. By reducing Bax levels and enhancing antiapoptotic Bcl-2 production, ESE prevented the release of interleukin-1β, tumor necrosis factor-α, and cyclooxygenase-2, as well as preventing hippocampal cell death after PTZ injection. ESE corrected the PTZ-induced imbalance in gamma-aminobutyric acid levels and increased the enzyme activity of Na+/K+-ATPase. Echinops spinosus is a potent neuromodulatory, antioxidant, antiinflammatory, and antiapoptotic plant that could be employed as a natural anticonvulsant in the future. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |