التفاصيل البيبلوغرافية
| العنوان: |
Mogamulizumab for post-transplant relapse of adult T-cell leukemia/lymphoma: a case study. |
| المؤلفون: |
Hirosawa, Makoto, Goto, Midori, Oku, Masahiko, Akao, Kenichi, Kitamura, Noriaki, Nakanishi, Tsukasa, Tanaka, Aya, Niino, Daisuke, Higashi, Takehiro, Morimoto, Hiroaki, Tsukada, Junichi |
| المصدر: |
International Journal of Hematology; Jan2023, Vol. 117 Issue 1, p143-148, 6p |
| مستخلص: |
Mogamulizumab (MOG), a humanized monoclonal anti-CCR4 antibody, exerts strong antibody-dependent cellular cytotoxic effects on CCR4-positive adult T-cell leukemia/lymphoma (ATLL) cells. As CCR4 is highly expressed on regulatory T cells as well as ATLL cells, pre-transplant MOG induces severe graft-versus-host disease (GvHD). However, limited data are available on post-transplant use of MOG for relapsed ATLL. Here we describe the case of a patient with ATLL who experienced post-transplant relapse with involvement of peripheral blood, skin, lungs, and lymph nodes. Neither tacrolimus dose reduction nor cytotoxic chemotherapy was effective, but a single dose of MOG (1 mg/kg) induced complete remission. After treatment with MOG, leukemic cells in the peripheral blood rapidly disappeared, and the skin, lymph node, and lung lesions gradually regressed. Most notably, the long-term remission was accompanied by recurrence of moderate acute GvHD (grade II, skin stage 2, gut stage 1, liver stage 0). Our findings indicate that MOG can augment allogeneic immune-mediated anti-tumor reactions through graft-versus-ATLL (GvATLL) even during post-transplant relapse involving the lymph nodes and lungs, along with inducing GvHD. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |