التفاصيل البيبلوغرافية
| العنوان: |
Transplacental transmission of hepatitis C virus infection. |
| المؤلفون: |
Iliescu, Dominic-Gabriel, Berbecaru, Elena-Iuliana-Anamaria, Istrate-Ofițeru, Anca-Maria, Nagy, Rodica Daniela, Rămescu, Cătălina, Enache, Alina-Iuliana, Vochin, Andreea, Ciobanu, Ștefan-Gabriel, Băluță, Ionuț-Daniel, Dîră, Laurențiu Mihai, Drocaș, Ileana, Zorilă, George-Lucian |
| المصدر: |
Ginecologia.ro; 2022 Supplement 2, Vol. 10, p24-24, 1/2p |
| مصطلحات موضوعية: |
HEPATITIS C, RUBELLA, AMNIOTIC liquid, VERTICAL transmission (Communicable diseases), CORD blood, HERPES simplex |
| مستخلص: |
Introduction. Vertical transmission of hepatitis C virus (HCV) occurs in rare cases (5-8%), more often during birth and, seldom, transplacental, before birth. Hepatitis C virus can cause acute or chronic hepatitis. Materials and method. We present the case of a 42-year-old woman, gravida 2, para 2, with 32 weeks of gestation. The ultrasound exam noticed fetal ascites, polyhydramnios and echogenic fetal bowel. The mother was tested for the TORCH panel, including HCV. Anti-HCV antibodies were present. We decided to perform fetal cordocentesis, paracentesis and amniocentesis. From cordocentesis we obtained approximately 8 ml of fetal blood, analyzed for: albumin, direct bilirubin, indirect bilirubin, total bilirubin, blood count, blood glucose, direct Coombs test, HCV RNA, IgM antibodies for cytomegalovirus/toxoplasmosis/Rubella/herpes simplex type 1 and 2. Also, 160 ml of fetal ascites fluid were sent for cytological and biochemical analysis, and 40 ml of clear amniotic fluid were used to detect infection with herpes simplex, Epstein-Barr or parvovirus. Results. The biochemical tests and blood count performed from the fetal blood were within normal range. The direct Coombs test was negative. HCV RNA was detected. Antibodies for cytomegalovirus/toxoplasmosis/Rubella/herpes simplex type 1 and 2, Epstein-Barr and parvovirus B19 were absent. The biochemical tests performed from the fetal ascites fluid showed: red blood cells 3000/mm³, leukocytes 835/mm³, glucose 57 mg/dL, albumin 1.90 g/dL, creatinine 0.53 mg/dL, urea 19 mg/dL, proteins 3.4 g/dL, positive Rivalta test. HCV RNA was detected. IgM antibodies for cytomegalovirus/toxoplasmosis/Rubella/herpes simplex type 1 and 2 were all absent. Fetal ascites markedly decreased and normal echogenicity of the bowel was noted. Conclusions. In rare cases, HCV can be transmitted vertically from the mother to the unborn baby. Cordocentesis and paracentesis helped us diagnose the fetus before birth and improve his prognosis after birth. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |