التفاصيل البيبلوغرافية
| العنوان: |
Oxidative Status as an Attribute for Selective Antitumor Activity of Platinum-Containing Nanoparticles against Hepatocellular Carcinoma. |
| المؤلفون: |
Wawrowicz, Kamil, Majkowska-Pilip, Agnieszka, Szwed, Marzena, Żelechowska-Matysiak, Kinga, Chajduk, Ewelina, Bilewicz, Aleksander |
| المصدر: |
International Journal of Molecular Sciences; Dec2022, Vol. 23 Issue 23, p14773, 17p |
| مصطلحات موضوعية: |
PLATINUM nanoparticles, HEPATOCELLULAR carcinoma, HER2 positive breast cancer, ANTINEOPLASTIC agents, REACTIVE oxygen species, NANOPARTICLES, NANOPARTICLES analysis |
| مستخلص: |
Overcoming the limitations for efficient and selective drug delivery is one of the most challenging obstacles for newly designed anticancer agents. In this study, we present two types of platinum-based nanoparticles (NP), ultrasmall 2 nm PtNPs and core-shell 30 nm Au@Pt, which can be highly cytotoxic in an oxidative environment and remain biologically inactive in cells with lower oxidative status. Our research highlighted the differences in platinum nanoparticle-induced chemotoxicity and is the first study examining its mechanism as a substantial aspect of Au@Pt/PtNPs biological activity. Selectively induced oxidative stress was found to be a primary trigger of NPs' toxicity. Significant differences between Au@Pt and PtNPs were observed especially during 24 h treatment, due to successful intranuclear PtNPs location (~13% of internalized fraction). Reactive oxygen species (ROS)-level induced from both NPs types were similar, while reduction of reduced glutathione (GSH) intracellular content was stronger after treatment with PtNPs. Any biological activity was found in HER2+ breast cancer cells, which have only slightly increased oxidative status. Platinum-containing nanoparticles are an interesting tool for the improvement of selectivity in anticancer therapies against hepatocellular carcinoma (HCC). Due to intranuclear uptake, 2 nm PtNPs seems to be more promising for further research for HCC therapy. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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