التفاصيل البيبلوغرافية
| العنوان: |
Target Cell Lysis by Natural Killer Cells is Influenced by Β2-Microglobulin Expression. |
| المؤلفون: |
Müllbacher, A., King, N. J. C. |
| المصدر: |
Scandinavian Journal of Immunology; Jul1989, Vol. 30 Issue 1, p21-29, 9p |
| مصطلحات موضوعية: |
CELLULAR control mechanisms, KILLER cells, MAJOR histocompatibility complex, HLA histocompatibility antigens, TRANSPLANTATION immunology, CELL communication, ANTIVIRAL agents |
| مستخلص: |
Natural killer (NK) cells form part of the vertebrate defence against viruses and tumours, but show only limited specificity. The molecule(s) recognized by NK cells on target cells are al present unknown. Major histocompatibility complex (MHC) class I antigen concentration on target cells is inversely correlated with NK cell lysis. Here we show that MHC class I-unassociated β2 microglobulin (β2;-m) expression is involved in NK ceil- target cell interaction. Two human MHC class I negative cell lines, Daudi and K562. are differentially susceptible to NK cell lysis, Daudi cells are β2-m-negative and resistant to NK lysis. K562 are β2-m-positive and highly susceptible to lysis by NK cells. Interferon (IFN) treatment augments β2-m expression and NK lysis of K562, but not in Daudi cells. NKcell lysisof K562. but not YAC-1 cells, can be inhibited by monoclonal anti-human β2-m antibody. Furthermore, susceptibility of mouse embryo fibroblasts (MEF) to NK lysis can be increased by infection with recombinant vaccinia virus expressing the human β2-m gene. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |