التفاصيل البيبلوغرافية
| العنوان: |
First Evidence of Gastroprotection by Schinus molle : Roles of Nitric Oxide, Prostaglandins, and Sulfhydryls Groups in Its Mechanism of Action. |
| المؤلفون: |
Sánchez-Mendoza, María Elena, López-Lorenzo, Yaraset, Cruz-Antonio, Leticia, Arrieta-Baez, Daniel, Pérez-González, Miranda Carolina, Arrieta, Jesús |
| المصدر: |
Molecules; Nov2022, Vol. 27 Issue 21, p7321, 11p |
| مصطلحات موضوعية: |
NITRIC oxide, PROSTAGLANDINS, PROSTAGLANDIN receptors, SULFHYDRYL group, COLUMN chromatography, LABORATORY rats, ETHANOL |
| مصطلحات جغرافية: |
MEXICO |
| مستخلص: |
Schinus molle is a plant traditionally used in Mexico to treat gastric disorders. However, no scientific evidence has been reported on its gastroprotective effect. The aim of the current contribution was to conduct a bioassay-guided study on S. molle to evaluate its gastroprotective activity in a model of Wistar rats given ethanol orally to induce gastric lesions. The hexane and dichloromethane extracts from the tested plant showed over 99% gastroprotection at a dose of 100 mg/kg. From the hexane extract, two of the three fractions (F1 and F2) afforded over 99% gastroprotection. The F1 fraction was subjected to column chromatography, which revealed a white solid. Based on the ESI-MS analysis, the two main compounds in this solid were identified. The predominant compound was probably a triterpene. This mixture of compounds furnished about 67% gastroprotection at a dose of 100 mg/kg. Pretreatment with L-NAME, indomethacin, and NEM was carried out to explore the possible involvement of nitric oxide, prostaglandins, and/or sulfhydryl groups, respectively, in the gastroprotective activity of the white solid. We found evidence for the participation of all three factors. No antisecretory activity was detected (tested by pylorus ligation). In conclusion, evidence is herein provided for the first time of the gastroprotective effect of S. molle. [ABSTRACT FROM AUTHOR] |
|
Copyright of Molecules is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder