التفاصيل البيبلوغرافية
| العنوان: |
The neural stem cell properties of Pkd2l1+ cerebrospinal fluid-contacting neurons in vivo. |
| المؤلفون: |
Liang Cao, Ming-Zhi Huang, Qiang Zhang, Zhang-Rong Luo, Yi Zhang, Ping-Jiang An, Lei-Luo Yang, Wei Tan, Chun-Qing Wang, Xiao-Wei Dou, Qing Li |
| المصدر: |
Frontiers in Cellular Neuroscience; 9/9/2022, Vol. 16, p1-12, 12p |
| مصطلحات موضوعية: |
NEURAL stem cells, FIBROBLAST growth factor 2, VASCULAR endothelial growth factors, NEURONS, SPINAL cord injuries, SPINAL cord |
| مستخلص: |
The neural stem cells (NSCs) in the ventricular-subventricular zone of the adult mammalian spinal cord may be of great benefit for repairing spinal cord injuries. However, the sources of NSCs remain unclear. Previously, we have confirmed that cerebrospinal fluid-contacting neurons (CSF-cNs) have NSC potential in vitro. In this study, we verified the NSC properties of CSF-cNs in vivo. In mouse spinal cords, Pkd2l1C CSF-cNs localized around the central canal express NSC markers. In vitro, Pkd2l1C CSF-cNs form a neurosphere and express NSC markers. Activation and proliferation of CSF-cNs can be induced by injection of the neurotrophic factors basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) into the lateral ventricle. Spinal cord injury (SCI) also induces NSC activation and proliferation of CSFcNs. Collectively, our results demonstrate that Pkd2l1C CSF-cNs have NSC properties in vivo and may be involved in SCI recovery. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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