التفاصيل البيبلوغرافية
| العنوان: |
RECENT ADVANCES IN THE STUDY OF DERIVATIVES OF (EZ)-N'-BENZYLIDENE-(2RS)-2-(6-CHLORO-9H-CARBAZOL-2-YL) PROPANOHYDRAZIDE. |
| المؤلفون: |
BORDEI, ALEXANDRA TEODORA (TELEHOIU), LIMBAN, CARMEN, NUȚĂ, DIANA CAMELIA, ZARAFU, IRINA, DENES, ELEONORA, MĂRUȚESCU, LUMINIȚA, CHIFIRIUC, MARIANA CARMEN, POPA, MARCELA, ARAMĂ, CORINA |
| المصدر: |
Farmacia; Jul/Aug2022, Vol. 70 Issue 4, p589-595, 7p |
| مصطلحات موضوعية: |
GRAM-negative bacteria, ENTEROCOCCUS faecalis, THERMAL analysis, PSEUDOMONAS aeruginosa, CANDIDA albicans |
| Abstract (English): |
This study aims to complete the molecular characterization of some compounds with the original structure, derivatives of (EZ) -N'-benzylidene-(2RS) -2-(6-chloro-9H-carbazol-2-yl) propanohydrazide, by HR-MS and thermal analysis. The results of the antimicrobial action tests are also presented. The tests were performed on two Gram-negative bacterial strains (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853), two Gram-positive bacterial strains (Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212) and one fungal strain (Candida albicans ATCC 10231) and including qualitative and quantitative tests, being also determined the anti-biofilm activity. Compounds 1a, 1d and 1b exhibited good in vitro antimicrobial activity, with a MIC (minimum inhibitory concentration) value of 0.31 mg/mL against Gram-positive bacterial and fungal strain. The results also indicated that the compounds are more potent against microbial biofilms. [ABSTRACT FROM AUTHOR] |
| Abstract (Romanian): |
Acest studiu își propune să completeze caracterizarea moleculară a unor compuși cu structură originală, derivați ai (EZ)-N'-benziliden-(2RS)-2-(6-cloro-9H-carbazol-2-il) propanohidrazidei prin analiză spectrală HR-MS și analiză termică. Sunt prezentate și rezultatele testării acțiunii antimicrobiane. Testele au fost efectuate pe două tulpini de bacterii Gram negative (Escherichia coli ATCC 25922 și Pseudomonas aeruginosa ATCC 27853), două tulpini de bacterii Gram pozitive (Staphylococcus aureus ATCC 25923 și Enterococcus faecalis ATCC 29212) și o tulpină fungică (Candida albicans ATCC 10231), utilizând metode de testare calitative și cantitative, fiind determinată inclusiv activitatea anti-biofilm. Compușii 1a, 1d și 1b au prezentat o activitate antimicrobiană bună in vitro, cu o valoare CMI (concentrație minimă inhibitorie) de 0,31 mg/mL împotriva bacteriilor Gram pozitive și a tulpinii fungice. Rezultatele au indicat, de asemenea, că acești compuși sunt mai activi împotriva biofilmelor microbiene. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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