التفاصيل البيبلوغرافية
| العنوان: |
Expression Levels and Activity of Rat Liver Lactate Dehydrogenase Isoenzymes in Alloxan Diabetes. |
| المؤلفون: |
Eprintsev, A. T., Bondareva, I. R., Selivanova, N. V. |
| المصدر: |
Biochemistry (Biokhimiya). Supplemental Series B, Biomedical Chemistry; Sep2022, Vol. 16 Issue 3, p210-215, 6p |
| مستخلص: |
A significant decrease in the activity of liver lactate dehydrogenase (LDH, EC 1.1.1.27) associated with a decrease in the expression of the corresponding genes was found in rats with alloxan-induced diabetes. The decrease in the LDH activity was due to the cytoplasmic isoform of this enzyme. It was found that the level of ldha and ldhb gene transcripts in the liver of healthy rats was higher than in animals with alloxan diabetes. The ldha gene expression demonstrated almost 9-fold decrease, while a decrease in the ldhb gene expression was less pronounced (just 1.25-fold). Our data indicate an important role of LDH in the adaptive response of cellular metabolism in the development of type I diabetes mellitus. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |