التفاصيل البيبلوغرافية
| العنوان: |
Inflammatory and Cardiac Biomarkers in Relation with Post-Acute COVID-19 and Mortality: What We Know after Successive Pandemic Waves. |
| المؤلفون: |
Lionte, Catalina, Sorodoc, Victorita, Haliga, Raluca Ecaterina, Bologa, Cristina, Ceasovschih, Alexandr, Petris, Ovidiu Rusalim, Coman, Adorata Elena, Stoica, Alexandra, Sirbu, Oana, Puha, Gabriela, Constantin, Mihai, Dumitrescu, Gabriela, Gorciac, Victoria, Chelariu, Andrei-Costin, Catana, Andreea Nicoleta, Jaba, Elisabeta, Sorodoc, Laurentiu |
| المصدر: |
Diagnostics (2075-4418); Jun2022, Vol. 12 Issue 6, p1373, 17p |
| مصطلحات موضوعية: |
MONOCYTE lymphocyte ratio, NEUTROPHIL lymphocyte ratio, COVID-19, BIOMARKERS, PROGNOSIS |
| مستخلص: |
Background: Biomarkers were correlated with mortality in critically ill COVID-19 patients. No prediction tools exist for noncritically ill COVID-19 patients. We aimed to compare the independent prognostic value of inflammation and cardiac biomarkers for post-acute COVID-19 patients and the 30-day mortality rate in noncritically ill COVID-19 patients, as well as the relation with the virus variant involved. Methods: This observational cohort study was conducted at an emergency clinical hospital between 1 October 2020 and 31 December 2021. We included consecutive patients with biomarkers determined within 24 h of presentation, followed up at least 30 days postdischarge. Results: Post-acute COVID-19 was diagnosed in 20.3% of the cases and the all-cause 30-day mortality rate was 35.1% among 978 patients infected with variants of concern. Neutrophil-to-lymphocyte ratio (1.06 [95%CI, 1.01–1.11], p = 0.015) and NT-pro BNP were correlated with 30-daymortality, while the monocyte-to-lymphocyte ratio (2.77 [95%CI, 1.10–6.94], p = 0.03) and NT-pro BNP (1.68 [95%CI, 1.00–2.84], p = 0.05) were correlated with post-acute COVID-19. High-sensitivity to troponin was associated with 30-day mortality (1.55 [95%CI, 1.00–2.42], p = 0.05). A Cox proportional-hazards model confirmed that NT-pro BNP was independently associated with mortality. NT-pro BNP remained independently associated with 30-day mortality during follow-up (1.29 [95%CI, 1.07–1.56], p = 0.007) after adjustment for confounders. Conclusion: Inflammation and cardiac biomarkers, determined upon admission and predischarge, in a cohort of hospitalized noncritically ill COVID-19 patients throughout successive pandemic waves, showed a predictive value for post-acute COVID-19 and 30-day mortality. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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