التفاصيل البيبلوغرافية
| العنوان: |
Genomic Characterization of Group A Streptococci Causing Pharyngitis and Invasive Disease in Colorado, USA, June 2016- April 2017. |
| المؤلفون: |
Li, Yuan, Dominguez, Samuel, Nanduri, Srinivas A, Rivers, Joy, Mathis, Saundra, Li, Zhongya, McGee, Lesley, Chochua, Sopio, Metcalf, Benjamin J, Beneden, Chris A Van, Beall, Bernard, Miller, Lisa, Van Beneden, Chris A |
| المصدر: |
Journal of Infectious Diseases; 5/15/2022, Vol. 225 Issue 10, p1841-1851, 11p |
| مصطلحات موضوعية: |
ANTIBIOTICS, STREPTOCOCCAL diseases, STREPTOCOCCUS, GENOMICS, DENVER Developmental Screening Test, RESEARCH funding, DRUG resistance in microorganisms, PHARYNGITIS, PHARMACODYNAMICS |
| مصطلحات جغرافية: |
COLORADO |
| مستخلص: |
Background: The genomic features and transmission link of circulating Group A Streptococcus (GAS) strains causing different disease types, such as pharyngitis and invasive disease, are not well understood.Methods: We used whole-genome sequencing to characterize GAS isolates recovered from persons with pharyngitis and invasive disease in the Denver metropolitan area from June 2016 to April 2017.Results: The GAS isolates were cultured from 236 invasive and 417 pharyngitis infections. Whole-genome sequencing identified 34 emm types. Compared with pharyngitis isolates, invasive isolates were more likely to carry the erm family genes (23% vs 7.4%, P<.001), which confer resistance to erythromycin and clindamycin (including inducible resistance), and covS gene inactivation (7% vs 0.5%, P<.001). Whole-genome sequencing identified 97 genomic clusters (433 isolates; 2-65 isolates per cluster) that consisted of genomically closely related isolates (median single-nucleotide polymorphism=3 [interquartile range, 1-4] within cluster). Thirty genomic clusters (200 isolates; 31% of all isolates) contained both pharyngitis and invasive isolates and were found in 11 emm types.Conclusions: In the Denver metropolitan population, mixed disease types were commonly seen in clusters of closely related isolates, indicative of overlapping transmission networks. Antibiotic-resistance and covS inactivation was disproportionally associated with invasive disease. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |