التفاصيل البيبلوغرافية
| العنوان: |
Detection of blaTEM, blaCTX-M, blaCMY, and blaSHV Genes Among Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolated from Migratory Birds Travelling to Bangladesh. |
| المؤلفون: |
Islam, Md. Saiful, Sobur, Md. Abdus, Rahman, Saifur, Ballah, Fatimah Mohammed, Ievy, Samina, Siddique, Mahbubul Pratik, Rahman, Marzia, Kafi, Md. Abdul, Rahman, Md. Tanvir |
| المصدر: |
Microbial Ecology; May2022, Vol. 83 Issue 4, p942-950, 9p |
| مصطلحات موضوعية: |
MIGRATORY birds, BETA-lactamase inhibitors, BETA lactamases, ESCHERICHIA coli, DRUG resistance in bacteria, POLYMERASE chain reaction, GENES |
| مصطلحات جغرافية: |
BANGLADESH |
| مستخلص: |
Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli cause severe health hazards. Migratory birds are reservoirs and transmitters of many pathogens including ESBL-producing E. coli. To examine migratory birds as potential carriers of ESBL-producing E. coli and E. coli-carrying antibiotic resistance genes, 55 PCR-positive E. coli isolates were screened using the disk diffusion method, double-disk synergy test, and further polymerase chain reaction (PCR) tests. Genes encoding resistance to tetracycline [tetA, 100% (35/35); tetB, 31.43% (11/35)], fluoroquinolone [qnrA, 35.71% (10/28); qnrB, 25% (7/28)], and streptomycin [aadA1, 90.24% (37/41)] were detected in the isolated E. coli. Of the 55 E. coli isolates, 21 (38.18%) were ESBL producers, and all of them were multidrug resistant. All the ESBL-producing E. coli isolates harbored at least two or more beta-lactamase genes, of which blaTEM, blaCMY, blaCTX-M, and blaSHV were detected in 95.24%, 90.48%, 85.71%, and 42.86% of isolates, respectively. All the beta-lactamase genes were present in four of the ESBL-producing E. coli isolates. Furthermore, 95.24% of ESBL-producing E. coli isolates were positive for one or more antibiotic resistance genes. To the best of our knowledge, this is the first study to detect E. coli-carrying antibiotic resistance genes including beta-lactamase blaCMY and blaSHV originating from migratory birds in Bangladesh. These results suggest that migratory birds are potential carriers of ESBL-producing E. coli along with other clinically important antibiotic resistance genes which may have detrimental impacts on human health. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |