التفاصيل البيبلوغرافية
| العنوان: |
The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer. |
| المؤلفون: |
Kussainova, Assiya, Bulgakova, Olga, Aripova, Akmaral, Khalid, Zumama, Bersimbaev, Rakhmetkazhi, Izzotti, Alberto |
| المصدر: |
Biomedicines; Feb2022, Vol. 10 Issue 2, p428, 1p |
| مصطلحات موضوعية: |
LUNG development, LUNG cancer, MICRORNA, MESSENGER RNA, NON-coding RNA, MITOCHONDRIAL pathology |
| مستخلص: |
MicroRNAs are short, non-coding RNA molecules regulating gene expression by inhibiting the translation of messenger RNA (mRNA) or leading to degradation. The miRNAs are encoded in the nuclear genome and exported to the cytosol. However, miRNAs have been found in mitochondria and are probably derived from mitochondrial DNA. These miRNAs are able to directly regulate mitochondrial genes and mitochondrial activity. Mitochondrial dysfunction is the cause of many diseases, including cancer. In this review, we consider the role of mitochondrial miRNAs in the pathogenesis of lung cancer with particular reference to radon exposure. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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