التفاصيل البيبلوغرافية
| العنوان: |
Advances in gene therapy for neurogenetic diseases: a brief review. |
| المؤلفون: |
Xie, Ying-Xuan, Lv, Wen-Qi, Chen, Yi-Kun, Hong, Shunyan, Yao, Xiang-Ping, Chen, Wan-Jin, Zhao, Miao |
| المصدر: |
Journal of Molecular Medicine; Mar2022, Vol. 100 Issue 3, p385-394, 10p |
| مصطلحات موضوعية: |
GENE therapy, GENETIC vectors, GENETIC transformation, GENOME editing, TREATMENT effectiveness, THERAPEUTICS, NEUROLOGICAL disorders, RNA editing |
| مستخلص: |
Neurogenetic diseases are neurological conditions with a genetic cause (s). There are thousands of neurogenetic diseases, and most of them are incurable. The development of bioinformatics and elucidation of the mechanism of pathogenesis have allowed the development of gene therapy approaches, which show great potential in treating neurogenetic diseases. Viral vectors delivery, antisense oligonucleotides, gene editing, RNA interference, and burgeoning viroid delivery technique are promising gene therapy strategies, and commendable therapeutic effects in the treatment of neurogenetic diseases have been achieved (Fig. 1). This review highlights a sampling of advances in gene therapies for neurogenetic disorders. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |