التفاصيل البيبلوغرافية
| العنوان: |
Raf and VEGF: emerging therapeutic targets in Kaposi's sarcoma-associated herpesvirus infection and angiogenesis in hematopoietic and nonhematopoietic tumors. |
| المؤلفون: |
Hamden, K E, Whitman, A G, Ford, P W, Shelton, J G, McCubrey, J A, Akula, S M |
| المصدر: |
Leukemia (08876924); Jan2005, Vol. 19 Issue 1, p18-26, 9p, 2 Diagrams, 2 Charts |
| مصطلحات موضوعية: |
VASCULAR endothelial growth factors, KAPOSI'S sarcoma, NEOVASCULARIZATION, IMMUNOREGULATION, HERPESVIRUS diseases, CYTOKINES, CELLS, HERPESVIRUSES |
| مستخلص: |
Kaposi's sarcoma-associated herpesvirus (KSHV) is etiologically associated with several cancers including Kaposi's sarcoma (KS), primary effusion lymphoma, and multicentric Castleman's disease. KSHV-mediated pathogenesis is dependent mainly on KSHV infection as well as on the microenvironment provided by the growth factors (GFs)/inflammatory cytokines (ICs). Recently, we determined that oncoprotein Raf enhances KSHV infection of target cells. Interestingly, Raf regulates the expression of a variety of GFs/ICs including those involved in angiogenesis such as vascular endothelial growth factor (VEGF). In this review, we discuss the effect of the Raf-GF/IC autocrine/paracrine loop on KSHV infection of both hematopoietic and nonhematopietic cells, and associated disease conditions.Leukemia (2005) 19, 18-26. doi:10.1038/sj.leu.2403532 Published online 7 October 2004 [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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