التفاصيل البيبلوغرافية
| العنوان: |
口腔鳞状细胞癌外周血循环肿瘤细胞检测 及其临床意义. (Chinese) |
| Alternate Title: |
Detection of peripheral blood circulating tumor cells in oral squamous cell carcinoma and its clinical significance. (English) |
| المؤلفون: |
张帅源, 秦硕, 李光辉, 易雅群, 付昊杰, 高雅靖, 孙明磊 |
| المصدر: |
West China Journal of Stomatology; Oct2021, Vol. 39 Issue 5, p591-597, 7p |
| مصطلحات موضوعية: |
SENSITIVITY & specificity (Statistics), DIAGNOSIS, SQUAMOUS cell carcinoma, TUMOR classification, UNIVERSITY hospitals |
| Abstract (English): |
This study aims to investigate the diagnostic value of peripheral blood circulating tumor cells (CTCs) in oral squamous cell carcinoma (OSCC) and its correlation with the clinicopathological features of OSCC. Methods Ninety-three patients diagnosed as OSCC in the First Affiliated Hospital of Zhengzhou University from May 2019 to May 2020 were selected as the experimental group, and 20 healthy volunteers were employed as the control group. The CTCs value of peripheral blood of the patients were measured by CTCs detection technology, and its clinical significance was analyzed. Results The CTCs values in the experimental group were higher than those in the con‐ trol group, and the difference was statistically significant (P<0.000 1). The CTCs value in the peripheral blood of patients in the experimental group were not correlated with gender, site of onset, and presence or absence of peripheral tissue infiltration (P>0.05), but was correlated with age (P=0.022), tumor T stage (P=0.02), tumor N stage (P= 0.007 5), tumor M stage (P=0.013), clinical stage (P=0.029), early or late stage (P=0.022), tumor differentiation degree (P<0.001), and node metastasis (P=0.006 4). The AUC value of CTCs in OSCC diagnosis was 0.925, and the energy effi‐ ciency was statistically significant [P=0.000, 95%CI (0.876, 0.974)]. When the CTC value was 8.450 FU/3 mL, the maxi‐ mum value of the Yoden index was 0.853, and the sensitivity and specificity of OSCC diagnosis were 90.3% and 95.0%, respectively. The AUC value of CTCs in the diagnosis of OSCC metastasis was 0.691, and the energy efficiency was sta‐ tistically significant [P=0.000, 95%CI (0.580, 0.803)]. When the blood CTC value was 12.250 FU/3 mL, the maximum value of Yoden index was 0.367, the sensitivity was 63.6%, and the specificity was 73.3%. Multivariate regression analy‐ sis showed that buccal tumor was negatively correlated with CTCs in patients with OSCC (P=0.001 08), N2 stage (P= 0.000 74) and M stage (P=0.026 38). High differentiation (P<0.000 1) and moderate differentiation (P=0.001 5) were negatively correlated with CTCs values in patients with OSCC. Conclusion Peripheral blood CTCs has important clini‐ cal value for early screening, auxiliary diagnosis, evaluation of metastasis, and determination of malignant degree, pro‐ gression, and pathological grade of OSCC and a relatively reliable tumor detection indicator. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
探讨外周血循环肿瘤细胞 （CTCs） 检测对口腔鳞状细胞癌 （OSCC） 的诊断价值及其与OSCC临 床病理特征的相关性。方法 选择2019年5月—2020年5月在郑州大学第一附属医院确诊为OSCC的患者93例为 试验组，20例健康志愿者为对照组。检测2组外周血的CTCs值，分析其相关临床意义。结果 试验组患者CTCs 值高于对照组，差异有统计学意义（P<0.000 1）。试验组外周血CTCs值与患者的性别、发病部位、有无周围组织 浸润无关 （P>0.05），与患者年龄相关 （P=0.022）、肿瘤 T 分期 （P=0.02）、N 分期 （P=0.007 5）、M 分期 （P= 0.013）、临床分期 （P=0.029）、早晚期相关 （P=0.022）、肿瘤分化程度 （P<0.001） 和淋巴结转移 （P=0.006 4） 相 关。应用 CTCs诊断 OSCC的 AUC值为 0.925，检验能效性有统计学意义[P=0.000，95%CI （0.876，0.974）]，当 CTCs值为8.450 FU/3 mL时，约登指数最大为0.853，诊断OSCC的敏感度为90.3%，特异性95.0%；应用CTCs诊 断 OSCC 转移的 AUC 值为 0.691，检验能效性有统计学意义[P=0.000，95%CI （0.580，0.803）]，当 CTCs 值是 12.250 FU/3 mL时，约登指数最大为0.367，敏感度为63.6%，特异性73.3%。多因素回归分析表明颊部肿瘤与OS‐ CC患者CTCs值呈负相关（P=0.001 08）；N2分期（P=0.000 74）及M分期（P=0.026 38） 与OSCC患者CTCs值呈正 相关；肿瘤分化程度中高分化 （P<0.000 1） 及中分化 （P=0.001 5） 与 OSCC患者 CTCs值呈负 相关。结论 外周CTCs的检测，对OSCC的早期筛查、辅助诊断、评估转移以及判断肿瘤的恶 性程度、进展情况、病理分级等均有较为重要的临床价值。 [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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