التفاصيل البيبلوغرافية
| العنوان: |
Effects of Bioinsecticidal Aegerolysin-Based Cytolytic Complexes on Non-Target Organisms. |
| المؤلفون: |
Panevska, Anastasija, Glavan, Gordana, Jemec Kokalj, Anita, Kukuljan, Veronika, Trobec, Tomaž, Žužek, Monika Cecilija, Vrecl, Milka, Drobne, Damjana, Frangež, Robert, Sepčić, Kristina |
| المصدر: |
Toxins; Jul2021, Vol. 13 Issue 7, p457-457, 1p |
| مصطلحات موضوعية: |
COLORADO potato beetle, WESTERN corn rootworm, BIOLOGICAL insecticides, INTRAVENOUS therapy, ARTHROPOD pests, HONEYBEES, PLEUROTUS ostreatus |
| مستخلص: |
Aegerolysin proteins ostreolysin A6 (OlyA6), pleurotolysin A2 (PlyA2) and erylysin A (EryA) produced by the mushroom genus Pleurotus bind strongly to an invertebrate-specific membrane sphingolipid, and together with a protein partner pleurotolysin B (PlyB), form transmembrane pore complexes. This pore formation is the basis for the selective insecticidal activity of aegerolysin/PlyB complexes against two economically important coleopteran pests: the Colorado potato beetle and the western corn rootworm. In this study, we evaluated the toxicities of these aegerolysin/PlyB complexes using feeding tests with two ecologically important non-target arthropod species: the woodlouse and the honey bee. The mammalian toxicity of the EryA/PlyB complex was also evaluated after intravenous administration to mice. None of the aegerolysin/PlyB complexes were toxic against woodlice, but OlyA6/PlyB and PlyA2/PlyB were toxic to honeybees, with 48 h mean lethal concentrations (LC50) of 0.22 and 0.39 mg/mL, respectively, in their food. EryA/PlyB was also tested intravenously in mice up to 3 mg/kg body mass, without showing toxicity. With no toxicity seen for EryA/PlyB for environmentally beneficial arthropods and mammals at the tested concentrations, these EryA/PlyB complexes are of particular interest for development of new bioinsecticides for control of selected coleopteran pests. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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