التفاصيل البيبلوغرافية
| العنوان: |
Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug Candidate. |
| المؤلفون: |
Soltane, Raya, Chrouda, Amani, Mostafa, Ahmed, Al-Karmalawy, Ahmed A., Chouaïb, Karim, dhahri, Abdelwaheb, Pashameah, Rami Adel, Alasiri, Ahlam, Kutkat, Omnia, Shehata, Mahmoud, Jannet, Hichem Ben, Gharbi, Jawhar, Ali, Mohamed A., Zecconi, Alfonso |
| المصدر: |
Pathogens; May2021, Vol. 10 Issue 5, p623, 1p |
| مصطلحات موضوعية: |
COVID-19, SARS-CoV-2, CORONAVIRUSES, PANDEMICS, ACID derivatives, COVID-19 treatment, NEURAMINIDASE |
| مستخلص: |
In late December 2019, a novel coronavirus, namely severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), escaped the animal–human interface and emerged as an ongoing global pandemic with severe flu-like illness, commonly known as coronavirus disease 2019 (COVID-19). In this study, a molecular docking study was carried out for seventeen (17) structural analogues prepared from natural maslinic and oleanolic acids, screened against SARS-CoV-2 main protease. Furthermore, we experimentally validated the virtual data by measuring the half-maximal cytotoxic and inhibitory concentrations of each compound. Interestingly, the chlorinated isoxazole linked maslinic acid (compound 17) showed promising antiviral activity at micromolar non-toxic concentrations. Thoughtfully, we showed that compound 17 mainly impairs the viral replication of SARS-CoV-2. Furthermore, a very promising SAR study for the examined compounds was concluded, which could be used by medicinal chemists in the near future for the design and synthesis of potential anti-SARS-CoV-2 candidates. Our results could be very promising for performing further additional in vitro and in vivo studies on the tested compound (17) before further licensing for COVID-19 treatment. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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