التفاصيل البيبلوغرافية
| العنوان: |
Pathological findings in central nervous system demyelination associated with infliximab. |
| المؤلفون: |
Kalinowska-Lyszczarz, Alicja, Fereidan-Esfahani, Mahboobeh, Guo, Yong, Lucchinetti, Claudia F, Tobin, W Oliver |
| المصدر: |
Multiple Sclerosis Journal; Aug2020, Vol. 26 Issue 9, p1124-1129, 6p, 2 Diagrams |
| مصطلحات موضوعية: |
CENTRAL nervous system, MYELIN sheath diseases, DEMYELINATION, TUMOR necrosis factors, MULTIPLE sclerosis, RHEUMATOID arthritis |
| مستخلص: |
Background: Tumor necrosis factor alpha (TNF-alpha) inhibitors, such as infliximab, are commonly used to treat rheumatoid arthritis (RA) and other immune-mediated disorders. Objective: To determine whether infliximab-associated central nervous system (CNS) demyelination can be differentiated from multiple sclerosis (MS). Methods: We present a case of pathologically proven CNS demyelination in a patient treated with infliximab and describe clinical–radiographic–neuropathological findings. Putative mechanisms of TNF-alpha inhibitor-associated CNS demyelination are described. Results and conclusion: Infliximab treatment is associated with CNS inflammatory demyelinating activity, which is histopathologically indistinguishable from MS. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |