التفاصيل البيبلوغرافية
| العنوان: |
Meniscus‐shaped cell‐free polyglycolic acid scaffold for meniscal repair in a sheep model. |
| المؤلفون: |
Cojocaru, Dan G., Hondke, Sylvia, Krüger, Jan P., Bosch, Claudia, Croicu, Cristian, Florescu, Sorin, Lazarescu, Adrian, Patrascu, Jenel‐Marian, Dauner, Martin, Gresser, Götz T., Endres, Michaela |
| المصدر: |
Journal of Biomedical Materials Research, Part B: Applied Biomaterials; Apr2020, Vol. 108 Issue 3, p809-818, 10p |
| مصطلحات موضوعية: |
SHEEP, COMPRESSIVE force, PLATELET-rich plasma, MENISCECTOMY, GLYCANS |
| مستخلص: |
Since loss of meniscus is correlated with an increasing risk for osteoarthritis, meniscal scaffolds are proposed as new strategies. Development of a suitable scaffold has to take into account differing meniscus thickness, exposure to compressive and tensile forces combined with high porosity and biocompatibility of the material. After physical testing of three flat scaffolds composed of different modified polyglycolic acid (PGA) fibers, a three‐dimensional meniscus‐shaped PGA‐hyaluronan implant was generated. Micro‐computed tomography showed 90% porosity in the outer area with 50% in the inner area of the implant. Biocompatibility and expression of meniscus typical cartilaginous genes were shown for human meniscus cells cultivated in the implant with 10% human serum or 5% platelet‐rich plasma for 14 days in vitro. The proof‐of‐concept study in sheep demonstrated proteoglycan‐ and collagen type I‐rich repair tissue formation in partial meniscectomy combined with a meniscus‐shaped PGA‐hyaluronan implant after 6 months. In contrast, the control showed nearly no repair tissue formation. Thus, meniscus‐shaped PGA‐hyaluronan implants might be a suitable therapeutic approach to support repair tissue formation in partial meniscectomy. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Biomedical Materials Research, Part B: Applied Biomaterials is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |