التفاصيل البيبلوغرافية
| العنوان: |
Comparison of Kidney Transcriptomic Profiles of Early and Advanced Diabetic Nephropathy Reveals Potential New Mechanisms for Disease Progression. |
| المؤلفون: |
Ying Fan, Zhengzi Yi, D'Agati, Vivette D., Zeguo Sun, Fang Zhong, Weijia Zhang, Jiejun Wen, Ting Zhou, Ze Li, Li He, Qunzi Zhang, Kyung Lee, John Cijiang He, Niansong Wang, Fan, Ying, Yi, Zhengzi, Sun, Zeguo, Zhong, Fang, Zhang, Weijia, Wen, Jiejun |
| المصدر: |
Diabetes; Dec2019, Vol. 68 Issue 12, p2301-2314, 14p, 2 Color Photographs, 5 Graphs, 1 Map |
| مصطلحات موضوعية: |
DIABETIC nephropathies, GLUCAGON-like peptide 1, DISEASE progression, RNA sequencing, PATHOLOGY, PEPTIDE receptors |
| مستخلص: |
To identify the factors mediating the progression of diabetic nephropathy (DN), we performed RNA sequencing of kidney biopsy samples from patients with early DN, advanced DN, and normal kidney tissue from nephrectomy samples. A set of genes that were upregulated at early but downregulated in late DN were shown to be largely renoprotective, which included genes in the retinoic acid pathway and glucagon-like peptide 1 receptor. Another group of genes that were downregulated at early but highly upregulated in advanced DN consisted mostly of genes associated with kidney disease pathogenesis, such as those related to immune response and fibrosis. Correlation with estimated glomerular filtration rate (eGFR) identified genes in the pathways of iron transport and cell differentiation to be positively associated with eGFR, while those in the immune response and fibrosis pathways were negatively associated. Correlation with various histopathological features also identified the association with the distinct gene ontological pathways. Deconvolution analysis of the RNA sequencing data set indicated a significant increase in monocytes, fibroblasts, and myofibroblasts in advanced DN kidneys. Our study thus provides potential molecular mechanisms for DN progression and association of differential gene expression with the functional and structural changes observed in patients with early and advanced DN. [ABSTRACT FROM AUTHOR] |
|
Copyright of Diabetes is the property of American Diabetes Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder